CAS 161696-76-0

Desmethylolanzapine

Description:

Desmethylolanzapine is a chemical compound that serves as a metabolite of the antipsychotic medication olanzapine, which is primarily used to treat schizophrenia and bipolar disorder. It is characterized by its structural similarity to olanzapine, lacking a methyl group at the nitrogen atom in the side chain. This alteration affects its pharmacological properties, including its affinity for various neurotransmitter receptors, particularly dopamine and serotonin receptors. Desmethylolanzapine is typically less potent than olanzapine but may still contribute to the overall therapeutic effects and side effects associated with olanzapine treatment. The compound is usually studied in the context of pharmacokinetics and pharmacodynamics to understand its role in the efficacy and safety profile of olanzapine. Its chemical properties include being a white to off-white solid, and it is soluble in organic solvents. As with many metabolites, its presence in biological systems can provide insights into drug metabolism and individual patient responses to treatment.

Formula: C₁₆H₁₈N₄S

InChI: InChI=1S/C16H18N4S/c1-11-10-12-15(20-8-6-17-7-9-20)18-13-4-2-3-5-14(13)19-16(12)21-11/h2-5,10,17,19H,6-9H2,1H3

InChI key: InChIKey=FHPIXVHJEIZKJW-UHFFFAOYSA-N

SMILES: CC1=CC=2C(=NC=3C(NC2S1)=CC=CC3)N4CCNCC4

Synonyms:

• 10H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(1-piperazinyl)-
• 2-Methyl-4-(1-Piperazinyl)-10H-Thieno-[2,3-b][1,5]Benzodiazepine
• 2-methyl-4-(piperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine
• 4'-Desmethylolanzapine
• Desmethylolanzapine
• Ly 170055
• N-Demethylolanzapine
• N-Desmethylolanzapine

N-Desmethylolanzapine

CAS: 161696-76-0

Color and Shape: Neat

Ref: LP-OLZ-1899-FB-10

N-Desmethylolanzapine, 1mg/ml in Acetonitrile

CAS: 161696-76-0

Color and Shape: Single Solution

Ref: LP-OLZ-1899-FB-1LA

N-desmethyl Olanzapine

CAS: 161696-76-0

N-desmethyl Olanzapine, a metabolite of Olanzapine, is created via CYP1A2 oxidative metabolism.

Formula: C₁₆H₁₈N₄S

Purity: 99.67%

Color and Shape: Solid

Molecular weight: 298.41

Ref: TM-T35716

N-desmethyl Olanzapine

CAS: 161696-76-0

N-desmethyl Olanzapine

Purity: ≥98%

Molecular weight: 298.41g/mol

Ref: 54-BUP00461

N-Desmethyl Olanzapine

CAS: 161696-76-0

Formula: C₁₆H₁₈N₄S

Color and Shape: Pale Yellow Solid

Molecular weight: 298.41

Ref: 4Z-O-016

N-Desmethylolanzapine

Controlled Product

CAS: 161696-76-0

Formula: C₁₆H₁₈N₄S

Color and Shape: Neat

Molecular weight: 298.41

Ref: 86-MM0329.01

N-Desmethyl Olanzapine

CAS: 161696-76-0

Formula: C₁₆H₁₈N₄S

Molecular weight: 298.41

Ref: ST-EA-CP-O1008

N-Demethyl Olanzapine

Controlled Product

CAS: 161696-76-0

Applications A metabolite of Olanzapine.

Formula: C₁₆H₁₈N₄S

Color and Shape: Brown

Molecular weight: 298.41

Ref: TR-D230970

N-Demethyl Olanzapine-d3

Controlled Product

CAS: 161696-76-0

Formula: C₁₆D₃H₁₅N₄S

Color and Shape: Neat

Molecular weight: 301.424

Ref: TR-D230973

N-Demethyl olanzapine

CAS: 161696-76-0

N-Demethyl olanzapine is a metabolite of olanzapine. It is primarily formed by the demethylation of olanzapine and its concentration in plasma can be used as an indicator of olanzapine use. N-Demethyl olanzapine has been shown to cause hepatic steatosis, which may affect the analytical method for determining this drug in human serum. This drug also has a number of side effects that are related to its pharmacokinetic properties, including interaction with other drugs, such as antipsychotics and antidepressants. The concentration–time curve for N-demethyl olanzapine can be measured using an electrochemical detector.

Formula: C₁₆H₁₈N₄S

Purity: Min. 95%

Color and Shape: Yellow Solid

Molecular weight: 298.41 g/mol

Ref: 3D-FD21007

10H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(1-piperazinyl)-

CAS: 161696-76-0

Formula: C₁₆H₁₈N₄S

Color and Shape: Solid

Molecular weight: 298.4059

Ref: IN-DA001VSF