CAS 161696-76-0: Desmethylolanzapine

Description: Desmethylolanzapine is a chemical compound that serves as a metabolite of the antipsychotic medication olanzapine, which is primarily used to treat schizophrenia and bipolar disorder. It is characterized by its structural similarity to olanzapine, lacking a methyl group at the nitrogen atom in the side chain. This alteration affects its pharmacological properties, including its affinity for various neurotransmitter receptors, particularly dopamine and serotonin receptors. Desmethylolanzapine is typically less potent than olanzapine but may still contribute to the overall therapeutic effects and side effects associated with olanzapine treatment. The compound is usually studied in the context of pharmacokinetics and pharmacodynamics to understand its role in the efficacy and safety profile of olanzapine. Its chemical properties include being a white to off-white solid, and it is soluble in organic solvents. As with many metabolites, its presence in biological systems can provide insights into drug metabolism and individual patient responses to treatment.

Formula: C₁₆H₁₈N₄S

InChI: InChI=1S/C16H18N4S/c1-11-10-12-15(20-8-6-17-7-9-20)18-13-4-2-3-5-14(13)19-16(12)21-11/h2-5,10,17,19H,6-9H2,1H3

InChI key: InChIKey=FHPIXVHJEIZKJW-UHFFFAOYSA-N

SMILES: N=1C=2C=CC=CC2NC=3SC(=CC3C1N4CCNCC4)C

Synonyms:

• 10H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(1-piperazinyl)-
• 2-Methyl-4-(1-Piperazinyl)-10H-Thieno-[2,3-b][1,5]Benzodiazepine
• 2-methyl-4-(piperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine
• 4'-Desmethylolanzapine
• Desmethylolanzapine
• Ly 170055
• N-Demethylolanzapine
• N-Desmethylolanzapine

10H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(1-piperazinyl)-

CAS: 161696-76-0

• Formula: C₁₆H₁₈N₄S
• Color and Shape: Solid
• Molecular weight: 298.4059

N-desmethyl Olanzapine

CAS: 161696-76-0

N-desmethyl Olanzapine, a metabolite of Olanzapine, is created via CYP1A2 oxidative metabolism.

• Formula: C₁₆H₁₈N₄S
• Purity: 99.1%
• Color and Shape: Solid
• Molecular weight: 298.41

N-Desmethyl Olanzapine

CAS: 161696-76-0

• Formula: C₁₆H₁₈N₄S
• Color and Shape: Pale Yellow Solid
• Molecular weight: 298.41

N-Desmethylolanzapine

CAS: 161696-76-0

• Formula: C₁₆H₁₈N₄S
• Color and Shape: Neat
• Molecular weight: 298.41

N-Desmethylolanzapine

CAS: 161696-76-0

• Formula: C₁₆H₁₈N₄S
• Color and Shape: Neat
• Molecular weight: 298.41

N-Demethyl Olanzapine

CAS: 161696-76-0

Applications A metabolite of Olanzapine.

• Formula: C₁₆H₁₈N₄S
• Color and Shape: Brown
• Molecular weight: 298.41

N-Demethyl Olanzapine-d3

CAS: 161696-76-0

• Formula: C₁₆D₃H₁₅N₄S
• Color and Shape: Neat
• Molecular weight: 301.424

N-Demethyl olanzapine

CAS: 161696-76-0

N-Demethyl olanzapine is a metabolite of olanzapine. It is primarily formed by the demethylation of …

• Formula: C₁₆H₁₈N₄S
• Purity: Min. 95%
• Color and Shape: Yellow Solid
• Molecular weight: 298.41 g/mol