CAS 161748-29-4

GLP-1 (9-36) AMIDE (HUMAN, BOVINE, GUINEA PIG, MOUSE, PORCINE, RAT)

Description:

GLP-1 (9-36) amide is a peptide derived from the glucagon-like peptide-1 (GLP-1), which plays a crucial role in glucose metabolism and appetite regulation. This specific fragment, which is an amide form, is produced through the enzymatic cleavage of the full-length GLP-1. It is characterized by its ability to interact with GLP-1 receptors, albeit with a different potency and efficacy compared to its longer counterparts. The peptide is known to exhibit various biological activities, including the modulation of insulin secretion and the inhibition of glucagon release, contributing to its potential therapeutic applications in diabetes management. The CAS number 161748-29-4 uniquely identifies this compound, which is relevant in research settings across multiple species, including humans, bovines, guinea pigs, mice, porcine, and rats. Its stability, solubility, and bioactivity make it a subject of interest in pharmacological studies aimed at understanding metabolic disorders and developing related treatments.

Formula: C₁₄₀H₂₁₄N₃₆O₄₃

Synonyms:

• Proglucagon (80-107) Amide (Human, Bovine, Guinea Pig, Mouse, Porcine, Rat)
• Preproglucagon (100-127) Amide (Human, Bovine, Guinea Pig, Mouse, Porcine, Rat)
• H-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Nh2
• Glucagon-Like Peptide 1 (9-36) Amide (Human, Bovine, Guinea Pig, Mouse, Porcine, Rat)

GLP-1 (9-36) amide (human, bovine, guinea pig, mouse, porcine, rat)

CAS: 161748-29-4

Glucagon-like peptide-1 (GLP-1) is efficiently degraded by the enzyme dipeptidyl peptidase IV (DPP IV), yielding the major metabolite GLP-1 (9-36) amide. GLP-1 (9-36) amide does not affect glucose disposal in mice either in the presence or absence of intact GLP-1 receptors or in the presence or absence of stimulated insulin levels. This suggests that the GLP-1 metabolite is not involved in the regulation of glucose homeostasis. Elahi et al. have shown that this GLP-1 metabolite acts as a weak insulinotropic agent and inhibits hepatic glucose production.

Formula: C₁₄₀H₂₁₄N₃₆O₄₃

Purity: ≥ 98%

Color and Shape: White Powder

Molecular weight: 3089.46

Ref: 01-4027697

GLP-1 (9-36) amide

CAS: 161748-29-4

GLP-1 (9-36) amide is an antagonist at the human GLP-1 receptor.

Formula: C₁₄₀H₂₁₄N₃₆O₄₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 3089.41

Ref: TM-TP2252

GLP-1 (9-36) amide trifluoroacetate

CAS: 161748-29-4

GLP-1 (9-36) amide trifluoroacetate is a bioactive peptide fragment derived from the full-length glucagon-like peptide-1 (GLP-1), an incretin hormone. It is typically obtained through enzymatic cleavage or synthetic processes involving solid-phase peptide synthesis. The mode of action of GLP-1 (9-36) amide involves binding to and modulating GLP-1 receptors, although it lacks the insulinotropic activity of its precursor GLP-1 (7-36) amide, making it a valuable tool for studying distinct signaling pathways and metabolic effects.

Formula: C₁₄₀H₂₁₄N₃₆O₄₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 3,089.41 g/mol

Ref: 3D-FG109155

GLP-1 (9-36) amide

CAS: 161748-29-4

Natural cleavage product of GLP-1 which, unlike GLP-1, does not affect either insulin secretion or glucose homeostasis.  GLP-1(9-36) has low affinity for, and acts as an antagonist to, the GLP-1 receptor.GLP-1 (9-36) does however display unique biological activities such as beneficial cardiovascular effects and reducing the production of reactive oxygen species (ROS). GLP-1 (9-36) also exerts important physiological effects on neuronal plasticity in the hippocampus, and inhibits chemokine-induced migration of human CD4-positive lymphocytes.GLP-1 (9-36) is formed from the breakdown of biologically active but highly unstable GLP-1 (7-36) amide by the ubiquitous serine protease, dipeptidyl peptidase-IV (DPP-IV).

Color and Shape: Powder

Molecular weight: 3,087.6 g/mol

Ref: 3D-CRB1000982

GLP-1 (9-36) amide

CAS: 161748-29-4

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₁₄₀H₂₁₄N₃₆O₄₃

Molecular weight: 3,089.44 g/mol

Ref: 3D-PP49952

GLP-1 (9-36) amide (human, bovine, guinea pig, mouse, porcine, rat)

CAS: 161748-29-4

Catalogue peptide; min. 95% purity

Formula: C₁₄₀H₂₁₄N₃₆O₄₃

Molecular weight: 3,089.48 g/mol

Ref: 3D-VAC-00364