CAS 161797-99-5

Ethyl 2-(4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylate

Description:

Ethyl 2-(4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylate, with the CAS number 161797-99-5, is an organic compound characterized by its thiazole and phenolic functional groups. This compound typically appears as a solid or crystalline substance and is known for its potential applications in pharmaceuticals and agrochemicals due to its biological activity. The presence of the ethyl ester group contributes to its solubility in organic solvents, while the hydroxyl group on the phenyl ring may enhance its reactivity and ability to form hydrogen bonds. The thiazole ring is known for its role in various biological processes, making this compound of interest in medicinal chemistry. Its molecular structure suggests potential interactions with biological targets, which could lead to various therapeutic effects. Additionally, the compound's stability and reactivity can be influenced by environmental factors such as pH and temperature, which are important considerations in its application and handling. Overall, this compound exemplifies the complexity and utility of heterocyclic compounds in chemical research and development.

Formula: C₁₃H₁₃NO₃S

InChI: InChI=1S/C13H13NO3S/c1-3-17-13(16)11-8(2)14-12(18-11)9-4-6-10(15)7-5-9/h4-7,15H,3H2,1-2H3

InChI key: InChIKey=LOCYSKNNFCGDTR-UHFFFAOYSA-N

SMILES: C(OCC)(=O)C=1SC(=NC1C)C2=CC=C(O)C=C2

Synonyms:

• 2-(4-Hydroxyphenyl)-4-Methylthiazole-5-Carboxylate
• 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
• 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxytic acid ethyl ester
• 5-Thiazolecarboxylic acid, 2-(4-hydroxyphenyl)-4-methyl-, ethyl ester
• Ethyl 2-(4-HydroxyPhenyl)-4-Methyl Thiazole-5-Carboxylate
• Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate
• Ethyl-2-(4-Hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylate
• Ethyl2-(4-hydroxy phenyl)-4-methylthiazole-5-carboxylate
• Febuxostat N-2

5-Thiazolecarboxylic acid, 2-(4-hydroxyphenyl)-4-methyl-, ethyl ester

CAS: 161797-99-5

Formula: C₁₃H₁₃NO₃S

Purity: 96%

Color and Shape: Solid

Molecular weight: 263.3122

Ref: IN-DA001VVY

Febuxostat Impurity 39

CAS: 161797-99-5

Formula: C₁₃H₁₃NO₃S

Color and Shape: White To Off-White Solid

Molecular weight: 263.31

Ref: 4Z-F-3953

Ethyl 2-(4-Hydroxyphenyl)-4-Methylthiazole-5-Carboxylate

CAS: 161797-99-5

Ethyl 2-(4-Hydroxyphenyl)-4-Methylthiazole-5-Carboxylate

Purity: 98%

Molecular weight: 263.31g/mol

Ref: 54-OR1013139

Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate

CAS: 161797-99-5

Applications Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate is used in the synthesis of the major metabolites of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.
References Li, X., et. al.: Lett. Org. Chem., 12, 217 (2015); Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)

Formula: C₁₃H₁₃NO₃S

Color and Shape: Neat

Molecular weight: 263.31

Ref: TR-E918910

Febuxostat Descyano Hydroxy Ethyl Ester

CAS: 161797-99-5

Formula: C₁₃H₁₃NO₃S

Molecular weight: 263.31

Ref: ST-EA-CP-F7041

2-(4-Hydroxyphenyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester

CAS: 161797-99-5

Formula: C₁₃H₁₃NO₃S

Purity: 96%

Color and Shape: Solid

Molecular weight: 263.31

Ref: 10-F025271

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

CAS: 161797-99-5

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate is an anticancer agent that belongs to the class of formamidines. It is synthesized by refluxing ethyl 4-hydroxyphenylacetic acid with hexamethylenetetramine and acetic acid in ethanol. After purification, it is converted to its active form by reacting with hydrochloric acid. Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate prevents the growth of cancer cells in culture by preventing DNA synthesis, which prevents RNA and protein synthesis. This agent has also been found to suppress paclitaxel production in cultured human breast cancer cells.

Formula: C₁₃H₁₃NO₃S

Purity: Min. 95%

Molecular weight: 263.31 g/mol

Ref: 3D-FE15829