CAS 161814-49-9: AMPRENAVIR

Description: Amprenavir is an antiretroviral medication primarily used in the treatment of HIV infection. It belongs to the class of drugs known as protease inhibitors, which work by inhibiting the protease enzyme, crucial for the viral replication process. The molecular formula of amprenavir is C20H27N3O5S, and it features a sulfonamide group, contributing to its pharmacological activity. Amprenavir is typically administered orally and is known for its relatively low pill burden compared to other antiretrovirals. It exhibits a moderate bioavailability and is metabolized primarily by the liver, with cytochrome P450 enzymes playing a significant role in its clearance. Common side effects may include gastrointestinal disturbances, rash, and potential lipid abnormalities. Due to the development of resistance, amprenavir is often used in combination with other antiretroviral agents to enhance efficacy and reduce the likelihood of viral resistance. Its stability and solubility characteristics make it suitable for formulation in various dosage forms, including capsules and oral solutions.

Formula: C₂₅H₃₅N₃O₆S

InChI: InChI=1S/C25H35N3O6S/c1-18(2)15-28(35(31,32)22-10-8-20(26)9-11-22)16-24(29)23(14-19-6-4-3-5-7-19)27-25(30)34-21-12-13-33-17-21/h3-11,18,21,23-24,29H,12-17,26H2,1-2H3,(H,27,30)/t21-,23-,24+/m0/s1

InChI key: InChIKey=YMARZQAQMVYCKC-OEMFJLHTSA-N

SMILES: O=C(OC1COCC1)NC(CC=2C=CC=CC2)C(O)CN(CC(C)C)S(=O)(=O)C3=CC=C(N)C=C3

Synonyms:

• 141W94
• 141W94, KVX-478, Agenerase, Prozei,
• Agenerase
• Amprenavir & its intermediates(R&D)
• Angenerase
• Carbamic acid, (1S,2R)-3-(4-aminophenyl)sulfonyl(2-methylpropyl)amino-2-hydroxy-1-(phenylmethyl)propyl-, (3S)-tetrahydro-3-furanyl ester
• Carbamic acid, N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-, (3S)-tetrahydro-3-furanyl ester
• Carbamic acid, [3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-, tetrahydro-3-furanyl ester, [3S-[3R*(1R*,2S*)]]-
• Kvx-478
• Prozei
• Samprenavir
• Vx 478
• tetrahydrofuran-3-yl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate

Carbamic acid, N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-, (3S)-tetrahydro-3-furanyl ester

CAS: 161814-49-9

• Formula: C₂₅H₃₅N₃O₆S
• Purity: 97%
• Color and Shape: Solid
• Molecular weight: 505.6269

Amprenavir

CAS: 161814-49-9

• Formula: C₂₅H₃₅N₃O₆S
• Purity: ≥ 98.0%
• Color and Shape: White to off-white powder
• Molecular weight: 505.63

Amprenavir

CAS: 161814-49-9

• Purity: ≥98%
• Molecular weight: 505.63g/mol

(S)-Tetrahydrofuran-3-Yl ((2S,3R)-4-((4-Amino-N-Isobutylphenyl)Sulfonamido)-3-Hydroxy-1-Phenylbutan-2-Yl)Carbamate

CAS: 161814-49-9

• Purity: 98%
• Molecular weight: 505.63g/mol

Amprenavir

CAS: 161814-49-9

• Formula: C₂₅H₃₅N₃O₆S
• Color and Shape: White To Off-White Solid
• Molecular weight: 505.63

Amprenavir

CAS: 161814-49-9

• Formula: C₂₅H₃₅N₃O₆S
• Color and Shape: Neat
• Molecular weight: 505.63

Amprenavir

CAS: 161814-49-9

Amprenavir (KVX-478) is a synthetic derivative of hydroxyethylamine sulfonamide that selectively binds to and inhibits …

• Formula: C₂₅H₃₅N₃O₆S
• Purity: 99.60% - 99.79%
• Color and Shape: Off-White To Pale Yellow
• Molecular weight: 505.63

Amprenavir

CAS: 161814-49-9

Applications A selective HIV protease inhibitor. An analogue of Ritonavir. References Adkins, J.C., et al.: …

• Formula: C₂₅H₃₅N₃O₆S
• Color and Shape: White To Beige
• Molecular weight: 505.63

Amprenavir

CAS: 161814-49-9

Anti-retroviral; HIV protease inhibitor

• Formula: C₂₅H₃₅N₃O₆S
• Purity: Min. 98 Area-%
• Color and Shape: White Off-White Powder
• Molecular weight: 505.63 g/mol