CAS 161832-65-1

Talampanel

Description:

Talampanel is a chemical compound known for its role as a selective antagonist of the AMPA receptor, which is a subtype of glutamate receptors in the central nervous system. Its primary application has been investigated in the context of neurological disorders, particularly epilepsy, due to its potential to modulate excitatory neurotransmission. Talampanel exhibits a unique structure that allows it to interact specifically with the AMPA receptor, thereby influencing synaptic transmission and neuronal excitability. The compound is characterized by its ability to cross the blood-brain barrier, making it relevant for central nervous system applications. Additionally, Talampanel has been studied for its neuroprotective properties, which may offer therapeutic benefits in conditions characterized by excessive neuronal activity. Its pharmacological profile includes a favorable safety margin, although further research is necessary to fully understand its efficacy and potential side effects in clinical settings. Overall, Talampanel represents a significant area of interest in the development of treatments for various neurological conditions.

Formula: C₁₉H₁₉N₃O₃

InChI: InChI=1/C19H19N3O3/c1-11-7-14-8-17-18(25-10-24-17)9-16(14)19(21-22(11)12(2)23)13-3-5-15(20)6-4-13/h3-6,8-9,11H,7,10,20H2,1-2H3/t11-/m1/s1

InChI key: InChIKey=JACAAXNEHGBPOQ-LLVKDONJSA-N

SMILES: C(C)(=O)N1N=C(C2=C(C=C3C(=C2)OCO3)C[C@H]1C)C4=CC=C(N)C=C4

Synonyms:

• (8R)-7-Acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine
• (R)-(-)-1-(4-Aminophenyl)-3-acetyl-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine
• 1-[(8R)-5-(4-Aminophenyl)-8-methyl-8,9-dihydro-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-7-yl]ethanone
• 1-[(8R)-5-(4-aminophenyl)-8-methyl-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-7-yl]ethanone
• 7H-1,3-Dioxolo[4,5-h][2,3]benzodiazepine, 7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-, (8R)-
• 7H-1,3-Dioxolo[4,5-h][2,3]benzodiazepine, 7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-, (R)-
• Gyki 53773
• Ly 300164
• Talampanel
• Ampanel
• AC1L4UWP
• CS-1843
• AC1Q5KPR
• C13670
• Talampanel >=97% (HPLC)
• (8R)-7-Acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine Talampanel(LY300164)
• TalaMpanel(LY300164)
• Talampanel (INN)
• Talampanel (GYKI 53773)
• AMPANEL; KINAMPA; TALAMPANEL (INN); GYKI 53773; AC1L4UWP; AC1Q5KPR

Talampanel

CAS: 161832-65-1

Talampanel

Purity: ≥95%

Molecular weight: 337.37g/mol

Ref: 54-BUP11509

Talampanel

CAS: 161832-65-1

Talampanel (LY-300164), an oral selective AMPA receptor antagonist, exhibits anti-seizure and neuroprotective properties.

Formula: C₁₉H₁₉N₃O₃

Purity: 98.3%

Color and Shape: Solid

Molecular weight: 337.37

Ref: TM-T16977