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CAS 161832-71-9

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GYKI 53784

Description:
GYKI 53784, with the CAS number 161832-71-9, is a chemical compound known for its role as a selective antagonist of the AMPA receptor, which is a subtype of glutamate receptors in the central nervous system. This compound is primarily studied for its potential neuroprotective effects and its ability to modulate excitatory neurotransmission, making it of interest in research related to neurological disorders such as epilepsy and neurodegenerative diseases. GYKI 53784 exhibits a high affinity for the AMPA receptor, which allows it to effectively inhibit receptor activity, thereby influencing synaptic transmission. Its chemical structure includes a distinctive bicyclic framework that contributes to its pharmacological properties. Additionally, GYKI 53784 has been investigated for its effects on cognitive functions and memory processes, highlighting its relevance in the field of neuropharmacology. As with many research compounds, its safety profile and long-term effects are subjects of ongoing investigation.
Formula:C19H20N4O3
InChI:InChI=1S/C19H20N4O3/c1-11-7-13-8-16-17(26-10-25-16)9-15(13)18(22-23(11)19(24)21-2)12-3-5-14(20)6-4-12/h3-6,8-9,11H,7,10,20H2,1-2H3,(H,21,24)/t11-/m1/s1
InChI key:InChIKey=SMGACXZFVXKEAX-LLVKDONJSA-N
SMILES:C(NC)(=O)N1N=C(C2=C(C=C3C(=C2)OCO3)C[C@H]1C)C4=CC=C(N)C=C4
Synonyms:
  • (8R)-5-(4-Aminophenyl)-8,9-dihydro-N,8-dimethyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide
  • LY 303070
  • 7H-1,3-Dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide, 5-(4-aminophenyl)-8,9-dihydro-N,8-dimethyl-, (8R)-
  • (-)-1-(4-Aminophenyl)-3-methylcarbamoyl-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine
  • 7H-1,3-Dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide, 5-(4-aminophenyl)-8,9-dihydro-N,8-dimethyl-, (R)-
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