CAS 161957-57-9

1-(2-Chloro-3-fluorophenyl)ethanone

Description:

1-(2-Chloro-3-fluorophenyl)ethanone, with the CAS number 161957-57-9, is an organic compound characterized by its ketone functional group and a substituted aromatic ring. The presence of both chlorine and fluorine atoms on the phenyl ring contributes to its unique chemical properties, including increased reactivity and potential for various applications in pharmaceuticals and agrochemicals. This compound typically exhibits a moderate to high polarity due to the electronegative halogen substituents, which can influence its solubility in different solvents. Additionally, the molecular structure suggests that it may participate in electrophilic aromatic substitution reactions, making it a valuable intermediate in organic synthesis. Its physical properties, such as boiling point and melting point, are influenced by the molecular weight and the presence of halogens. Safety data should be consulted for handling, as halogenated compounds can pose health risks. Overall, 1-(2-Chloro-3-fluorophenyl)ethanone is a significant compound in the realm of synthetic organic chemistry.

Formula: C₈H₆ClFO

InChI: InChI=1S/C8H6ClFO/c1-5(11)6-3-2-4-7(10)8(6)9/h2-4H,1H3

InChI key: InChIKey=YLXXXDDQBMAZKT-UHFFFAOYSA-N

SMILES: C(C)(=O)C1=C(Cl)C(F)=CC=C1

Synonyms:

• 1-(2-Chloro-3-fluorophenyl)ethan-1-one
• 2'-Chloro-3'-fluoroacetophenone
• Ethanone, 1-(2-chloro-3-fluorophenyl)-
• 1-(2-Chloro-3-fluorophenyl)ethanone

Ethanone, 1-(2-chloro-3-fluorophenyl)-

CAS: 161957-57-9

Formula: C₈H₆ClFO

Purity: 98%

Color and Shape: Liquid

Molecular weight: 172.5840

Ref: IN-DA001SK3

2'-Chloro-3'-fluoroacetophenone

CAS: 161957-57-9

2'-Chloro-3'-fluoroacetophenone

Purity: 97%

Molecular weight: 172.58g/mol

Ref: 54-PC408052

1-(2-Chloro-3-fluorophenyl)ethanone

CAS: 161957-57-9

Formula: C₈H₆ClFO

Purity: 98%

Color and Shape: Liquid

Molecular weight: 172.58

Ref: 10-F216768

1-(2-Chloro-3-fluorophenyl)ethanone

Controlled Product

CAS: 161957-57-9

Applications 1-(2-Chloro-3-fluorophenyl)ethanone was used to prepare novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases.
References Steinig, A., et al.: Bioorg. Med. Chem. Lett., 23, 4381 (2013)

Formula: C₈H₆ClFO

Color and Shape: Neat

Molecular weight: 172.584

Ref: TR-C380325