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CAS 161967-81-3

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Grepafloxacin hydrochloride

Description:
Grepafloxacin hydrochloride is a synthetic fluoroquinolone antibiotic that exhibits broad-spectrum antibacterial activity. It is primarily effective against a variety of Gram-positive and Gram-negative bacteria, making it useful in treating respiratory and urinary tract infections. The compound functions by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and transcription. Grepafloxacin is characterized by its relatively high oral bioavailability and a favorable pharmacokinetic profile, which allows for effective dosing regimens. As a hydrochloride salt, it is typically more soluble in water, enhancing its bioavailability. The substance may also exhibit side effects common to fluoroquinolones, such as gastrointestinal disturbances and potential effects on the central nervous system. Additionally, it is important to consider the potential for resistance development with its use, as is the case with many antibiotics. Overall, Grepafloxacin hydrochloride represents a significant option in the antibiotic arsenal, although its clinical use may be influenced by local resistance patterns and regulatory status.
Formula:C19H22FN3O3·ClH
InChI:InChI=1S/C19H22FN3O3.ClH/c1-10-8-22(6-5-21-10)15-7-14-16(11(2)17(15)20)18(24)13(19(25)26)9-23(14)12-3-4-12;/h7,9-10,12,21H,3-6,8H2,1-2H3,(H,25,26);1H
InChI key:InChIKey=IEPMBYOIQGCVHO-UHFFFAOYSA-N
SMILES:O=C1C=2C(N(C=C1C(O)=O)C3CC3)=CC(=C(F)C2C)N4CC(C)NCC4.Cl
Synonyms:
  • 1-Cyclopropyl-6-Fluoro-5-Methyl-7-(3-Methylpiperazin-1-Yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid Hydrochloride (1:1)
  • 1-Cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid hydrochloride (1:1)
  • 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-, hydrochloride (1:1)
  • 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-, monohydrochloride
  • Grepafloxacin Hcl
  • Opc 17116
  • Raxar
  • Vaxar
  • dl-Grepafloxacin hydrochloride
  • Grepafloxacin hydrochloride
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