CAS 1619903-54-6

LY2857785

CAS: 1619903-54-6

Formula: C₂₆H₃₆N₆O

Purity: 98%

Color and Shape: Solid

Molecular weight: 448.6036

Ref: IN-DA00ABKP

LY2857785

CAS: 1619903-54-6

LY2857785

Purity: ≥95%

Molecular weight: 448.6g/mol

Ref: 54-BUP04840

LY2857785

CAS: 1619903-54-6

LY2857785 is a type I competitive and reversible ATP kinase inhibitor against CDK7/CDK8/CDK9 (IC50s: 246 nM/16 nM/11 nM).

Formula: C₂₆H₃₆N₆O

Purity: 99.68%

Color and Shape: Solid Powder

Molecular weight: 448.6

Ref: TM-TQ0060

LY2857785

Controlled Product

CAS: 1619903-54-6

Formula: C₂₆H₃₆N₆O

Color and Shape: Neat

Molecular weight: 448.604

Ref: TR-L468960

LY2857785

CAS: 1619903-54-6

LY2857785 is a potent and selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). It inhibits the proliferation of cancer cells by interfering with cellular organelles, such as the mitochondria. LY2857785 has been shown to potently inhibit the proliferation of lymphocytic leukemia and fibrolamellar carcinoma cells. Inhibition of CDK4/6 activity leads to a decrease in transcriptional regulation, which may be due to an inhibition of cyclin D1 expression. The mechanism studies revealed that LY2857785 synergistically interacts with a number of inflammatory bowel disease drugs, including thalidomide and 5-aminosalicylic acid. This drug is effective against chronic lymphocytic leukemia at doses lower than those required for cancer treatment, making it a potential candidate for the prevention or treatment of this disease.

Formula: C₂₆H₃₆N₆O

Purity: Min. 95%

Molecular weight: 448.6 g/mol

Ref: 3D-UPC90354