CAS 1620458-09-4: (2R,4S,4aS)-11-Fluoro-1,2,4,4a-tetrahydro-2,4-dimethyl-8-[(4S)-4-methyl-2-oxo-3-oxazolidinyl]spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5(6H),5′(2′H)-pyrimidine]-2′,4′,6′(1′H,3′H)-trione

Description: The chemical substance known as (2R,4S,4aS)-11-Fluoro-1,2,4,4a-tetrahydro-2,4-dimethyl-8-[(4S)-4-methyl-2-oxo-3-oxazolidinyl]spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5(6H),5′(2′H)-pyrimidine]-2′,4′,6′(1′H,3′H)-trione, with the CAS number 1620458-09-4, is a complex organic compound characterized by its intricate molecular structure, which includes multiple functional groups and stereocenters. This compound features a spirocyclic framework, indicative of its unique three-dimensional arrangement, which can significantly influence its biological activity and interactions. The presence of a fluorine atom suggests potential applications in medicinal chemistry, as fluorinated compounds often exhibit enhanced metabolic stability and bioactivity. Additionally, the oxazolidinyl and isoxazolo moieties may contribute to its pharmacological properties, making it a candidate for further research in drug development. Its specific stereochemistry is crucial for determining its reactivity and interaction with biological targets, highlighting the importance of chirality in pharmaceutical design. Overall, this compound represents a sophisticated example of modern synthetic organic chemistry.

Formula: C₂₂H₂₂FN₅O₇

InChI: InChI=1S/C22H22FN5O7/c1-8-7-33-21(32)28(8)17-12-4-11-5-22(18(29)24-20(31)25-19(22)30)16-10(3)34-9(2)6-27(16)14(11)13(23)15(12)35-26-17/h4,8-10,16H,5-7H2,1-3H3,(H2,24,25,29,30,31)/t8-,9+,10-,16+/m0/s1

InChI key: InChIKey=ZSWMIFNWDQEXDT-ZESJGQACSA-N

SMILES: O=C1NC(=O)C2(C(=O)N1)CC3=CC4=C(ON=C4N5C(=O)OCC5C)C(F)=C3N6CC(OC(C)C62)C

Synonyms:

• Spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5(6H),5′(2′H)-pyrimidine]-2′,4′,6′(1′H,3′H)-trione, 11-fluoro-1,2,4,4a-tetrahydro-2,4-dimethyl-8-[(4S)-4-methyl-2-oxo-3-oxazolidinyl]-, (2R,4S,4aS)-
• Zoliflodacin
• ETX 0914
• AZD 0914
• (2R,4S,4aS)-11-Fluoro-1,2,4,4a-tetrahydro-2,4-dimethyl-8-[(4S)-4-methyl-2-oxo-3-oxazolidinyl]spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5(6H),5′(2′H)-pyrimidine]-2′,4′,6′(1′H,3′H)-trione

Zoliflodacin

CAS: 1620458-09-4

Zoliflodacin (ETX0914) (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor.

• Formula: C₂₂H₂₂FN₅O₇
• Purity: 99.51% - 99.82%
• Color and Shape: Solid
• Molecular weight: 487.44

AZD 0914

CAS: 1620458-09-4

Inhibitor of bacterial DNA gyrase with potent antibacterial activity against Gram negative, Gram positive and …

• Formula: C₂₂H₂₂FN₅O₇
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 487.44 g/mol