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CAS 16205-32-6

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2-fluoroestradiol

Description:
2-Fluoroestradiol is a synthetic derivative of estradiol, which is a primary female sex hormone. This compound features a fluorine atom substituted at the second carbon position of the estradiol structure, which can influence its biological activity and receptor binding properties. Like other estrogens, 2-fluoroestradiol interacts with estrogen receptors, potentially exhibiting estrogenic or anti-estrogenic effects depending on the context of its use. It is often studied for its potential applications in hormone replacement therapy and cancer treatment, particularly in estrogen-sensitive tumors. The presence of the fluorine atom may enhance metabolic stability and alter pharmacokinetics compared to natural estrogens. In terms of physical properties, 2-fluoroestradiol is typically a solid at room temperature and may exhibit moderate solubility in organic solvents. Safety and handling precautions are essential, as with any chemical substance, due to potential biological effects and toxicity. Overall, 2-fluoroestradiol represents an important compound in medicinal chemistry and endocrinology research.
Formula:C18H23FO2
InChI:InChI=1/C18H23FO2/c1-18-7-6-11-12(14(18)4-5-17(18)21)3-2-10-8-16(20)15(19)9-13(10)11/h8-9,11-12,14,17,20-21H,2-7H2,1H3
SMILES:CC12CCC3C(CCc4cc(c(cc34)F)O)C1CCC2O
Synonyms:
  • Nsc 97849
  • Estra-1,3,5(10)-triene-3,17-diol, 2-fluoro-, (17beta)-
  • (17Beta)-2-Fluoroestra-1(10),2,4-Triene-3,17-Diol
  • 2-Fluoroestra-1(10),2,4-Triene-3,17-Diol
  • 2-Fluoroestradiol
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  • 2-Fluoroestradiol
    Biosynth
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    2-Fluoroestradiol

    Controlled Product
    CAS:
    2-Fluoroestradiol is a synthetic form of 17β-estradiol that has been shown to inhibit the growth of tumor cells in an experimental model. 2-Fluoroestradiol binds to the estrogen receptor and inhibits the production of proteins needed for cell division, thus causing cancer. This drug has also been shown to inhibit lipoprotein lipase activity in rat liver microsomes, which may be due to its ability to induce chemical reactions. In addition, 2-fluoroestradiol inhibits lipid synthesis in fat cells and decreases lipogenesis in granulosa cells from ovaries. The inhibition of triglyceride synthesis by 2-fluoroestradiol is probably due to its ability to inhibit enzyme induction and increase the expression of mRNA for protein synthesis.
    Formula:C18H23FO2
    Purity:Min. 95%
    Molecular weight:290.37 g/mol

    Ref: 3D-FF77149

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