CAS 16208-51-8

Disodium 2,2′-dithiobis(ethanesulfonate)

Description:

Disodium 2,2′-dithiobis(ethanesulfonate), commonly referred to as DTNB or Ellman's reagent, is a chemical compound widely used in biochemistry for the quantification of thiol groups in proteins and other biomolecules. It appears as a yellow crystalline powder and is soluble in water, making it suitable for various aqueous applications. The compound features two sulfonate groups and a dithiobis linkage, which contributes to its reactivity with thiols, leading to the formation of a colored product that can be measured spectrophotometrically. DTNB is valued for its stability and ease of use, allowing for the rapid assessment of thiol concentrations in biological samples. Additionally, it is often employed in enzyme assays and studies involving redox reactions. Safety considerations include handling it with care, as it can be irritating to skin and eyes. Overall, DTNB is a crucial reagent in biochemical research, particularly in studies related to protein structure and function.

Formula: C₄H₁₀O₆S₄·2Na

InChI: InChI=1S/C4H10O6S4.2Na/c5-13(6,7)3-1-11-12-2-4-14(8,9)10;;/h1-4H2,(H,5,6,7)(H,8,9,10);;

InChI key: InChIKey=KBFJUSPXGQWLBO-UHFFFAOYSA-N

SMILES: C(S(=O)(=O)O)CSSCCS(=O)(=O)O.[Na]

Synonyms:

• 16208-51-8
• 2,2′-Dithiodi-1-ethanesulfonic acid disodium salt
• Bis(2-sulfoethyl)disulfide disodium salt
• Bnp 7787
• Disodium 2,2'-disulfanediyldiethanesulfonate
• Disodium 2,2′-dithiobis(ethanesulfonate)
• Disodium 2,2′-dithiodiethanesulfonate
• Ethanesulfonic Acid, 2,2'-Dithiobis-, Sodium Salt (1:2)
• Ethanesulfonic acid, 2,2′-dithiobis-, disodium salt
• Ethanesulfonic acid, 2,2′-dithiodi-, disodium salt
• NSC 716976

Ethanesulfonic acid, 2,2'-dithiobis-, sodium salt (1:2)

CAS: 16208-51-8

Formula: C₄H₈Na₂O₆S₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 326.3423

Ref: IN-DA001SQJ

Dimesna

CAS: 16208-51-8

Dimesna

Purity: ≥98%

Molecular weight: 326.34g/mol

Ref: 54-BUP16907

Dimesna

CAS: 16208-51-8

Dimesna (BNP-7787) is a synthetic derivative of dithio-ethane sulfonate with uroprotective properties.

Formula: C₄H₈Na₂O₆S₄

Purity: 99.90%

Color and Shape: Solid

Molecular weight: 326.34

Ref: TM-T1672

Dimesna

CAS: 16208-51-8

Dimesna

Formula: C₄H₈O₆S₄·2Na

Purity: ≥95%

Color and Shape: off white powder

Molecular weight: 326.34g/mol

Ref: 54-OR303346

Dimesna

Controlled Product

CAS: 16208-51-8

Impurity Mesna EP Impurity D
Applications Dimesna (Mesna EP Impurity D) reacts with acrolein and other urotoxic metabolites of oxazaphosphorines (cyclophosphamide or ifosfamide) to form stable, non-urotoxic compounds. Mesna does not have any antitumour activity, nor does it appear to interfere with the antitumour activity of antineoplastic drugs. This medication is used to protect the bladder wall from the harmful effects of some cancer-fighting drugs.
References Yang, C., et al.: J. Biol. Chem., 262, 3086 (1987), Boven, E., et al.: Eur. J. Cancer, 38, 1148 (2002), Verschraagen, M., et al.: Clin. Pharmacol. Ther., 74, 157 (2003),

Formula: C₄H₈O₆S₄·2Na

Color and Shape: White To Off-White

Molecular weight: 326.34

Ref: TR-D460660

Dimesna

CAS: 16208-51-8

Dimesna is a disulfide-containing, water-soluble sodium citrate that is used as an antioxidant and chemotherapeutic agent. Dimesna has been shown to have anticancer activity in vitro and in vivo. It also has the ability to protect cells from cisplatin-induced nephrotoxicity. Dimesna can be used for the treatment of solid tumours and diabetic neuropathy, but it does not have any significant effects on healthy cells. Dimesna is an active analogue of cisplatin and may be useful for treating patients with cisplatin-induced acute toxicities.

Formula: C₄H₈Na₂O₆S₄

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 326.35 g/mol

Ref: 3D-FD22160

Sodium 2,2′-disulfanediyldiethanesulfonate

CAS: 16208-51-8

Formula: C₄H₈Na₂O₆S₄

Purity: 95.0%

Molecular weight: 326.32

Ref: 10-F242050