CAS 1621096-79-4

TCO-PEG4-NHS Ester

Description:

TCO-PEG4-NHS Ester, with the CAS number 1621096-79-4, is a chemical compound that serves as a versatile linker in bioconjugation applications. It features a trans-cyclooctene (TCO) moiety, which is known for its rapid and selective reaction with tetrazine derivatives, enabling efficient labeling and imaging in biological systems. The PEG4 (polyethylene glycol) segment enhances the solubility and biocompatibility of the compound, making it suitable for use in aqueous environments and reducing potential immunogenicity. The NHS (N-hydroxysuccinimide) ester functionality allows for the formation of stable amide bonds with primary amines, facilitating the conjugation to proteins, peptides, or other biomolecules. This compound is particularly valuable in the fields of drug delivery, diagnostics, and therapeutic development, where precise targeting and minimal off-target effects are crucial. Overall, TCO-PEG4-NHS Ester is characterized by its reactivity, solubility, and ability to form stable conjugates, making it a powerful tool in chemical biology and medicinal chemistry.

Formula: C₂₄H₃₈N₂O₁₀

Synonyms:

• TCO-PEG4-NHS Ester,Trans-Cyclooctene-PEG4-NHS ester
• TCO4-PEG4-NHS
• 5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(4E)-4-cycloocten-1-yl 17-(2,5-dioxo-1-pyrrolidinyl) ester

trans-Cyclooctene-PEG(4)-carboxy succinimidyl ester

CAS: 1621096-79-4

Formula: C₂₄H₃₈N₂O₁₀

Purity: 90.0%

Molecular weight: 514.5659

Ref: IN-DA00VRMD

(E)-TCO-PEG4-NHS ester

CAS: 1621096-79-4

(E)-TCO-PEG4-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.

Formula: C₂₄H₃₈N₂O₁₀

Color and Shape: Solid

Molecular weight: 514.572

Ref: TM-T39092

TCO-PEG4-NHS ester trans-cyclooctene-PEG4-NHS ester

CAS: 1621096-79-4

TCO-PEG4-NHS ester trans-cyclooctene-PEG4-NHS ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. TCO-PEG4-NHS ester trans-cyclooctene-PEG4-NHS ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Formula: C₂₄H₃₈N₂O₁₀

Purity: Min. 95%

Molecular weight: 514.6 g/mol

Ref: 3D-WPC09679

TCO-PEG4-NHS (contains 6% Dichloromethane at maximum)

CAS: 1621096-79-4

Formula: C₂₄H₃₈N₂O₁₀

Purity: >90.0%(HPLC)

Color and Shape: White to Light yellow clear liquid to cloudy liquid

Molecular weight: 514.57

Ref: 3B-T3949