CAS 162359-55-9

Fingolimod

Description:

Fingolimod is a synthetic sphingosine analog primarily used as an immunomodulatory drug for the treatment of multiple sclerosis. Its chemical structure allows it to interact with sphingosine-1-phosphate (S1P) receptors, leading to the sequestration of lymphocytes in lymph nodes and a reduction in their circulation in the bloodstream, thereby modulating immune responses. Fingolimod is characterized by its ability to cross the blood-brain barrier, which is crucial for its therapeutic effects in neurological conditions. The substance is typically administered orally and has a relatively long half-life, necessitating careful monitoring of patients for potential side effects, which can include bradycardia, elevated liver enzymes, and increased risk of infections. Fingolimod's pharmacokinetics are influenced by factors such as metabolism via the cytochrome P450 system, particularly CYP4F2, and its bioavailability can be affected by food intake. Overall, Fingolimod represents a significant advancement in the management of autoimmune diseases, particularly in reducing the frequency of relapses in multiple sclerosis patients.

Formula: C₁₉H₃₃NO₂

InChI: InChI=1S/C19H33NO2/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22/h9-12,21-22H,2-8,13-16,20H2,1H3

InChI key: InChIKey=KKGQTZUTZRNORY-UHFFFAOYSA-N

SMILES: C(CC(CO)(CO)N)C1=CC=C(CCCCCCCC)C=C1

Synonyms:

• 1,3-Propanediol, 2-amino-2-[2-(4-octylphenyl)ethyl]-
• 2-(4-Octylphenylethyl)-2-Aminopropane-1,3-Diol
• 2-Amino-2-[2-(4-Octylphenyl)Ethyl]Propane-1,3-Diol
• 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propandiol
• 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol
• Fingolimod
• Gilenia

Fingolimod Hydrochloride

CAS: 162359-55-9, 162359-56-0

Formula: C₁₉H₃₃NO₂·HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 343.94

Ref: 3B-F1018

1,3-Propanediol, 2-amino-2-[2-(4-octylphenyl)ethyl]-

CAS: 162359-55-9

Formula: C₁₉H₃₃NO₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 307.4708

Ref: IN-DA001T0Z

Fingolimod

CAS: 162359-55-9

Fingolimod

Purity: ≥98%

Molecular weight: 307.47g/mol

Ref: 54-BUP17279

Fingolimod

CAS: 162359-55-9

Fingolimod

Purity: 99%

Molecular weight: 307.47g/mol

Ref: 54-OR1024608

Fingolimod

CAS: 162359-55-9

Formula: C₁₉H₃₃NO₂

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 307.48

Ref: 3B-F1395

Fingolimod

CAS: 162359-55-9

Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).

Formula: C₁₉H₃₃NO₂

Purity: 99.53% - 99.6%

Color and Shape: Solid

Molecular weight: 307.47

Ref: TM-T7939

Fingolimod

Controlled Product

CAS: 162359-55-9

Applications Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.
References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),

Formula: C₁₉H₃₃NO₂

Color and Shape: Neat

Molecular weight: 307.47

Ref: TR-F342045

FINGOLIMOD

CAS: 162359-55-9

Purity: 97%

Molecular weight: 307.4779968

Ref: 10-F835714

Fingolimod

CAS: 162359-55-9

Sphingosine-1-phosphate receptor modulator; immunomodulator

Formula: C₁₉H₃₃NO₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 307.47 g/mol

Ref: 3D-FA46838

Fingolimod - Bio-X ™

CAS: 162359-55-9

Fingolimod is a sphingosine 1-phosphate receptor modulator that is used in the treatment of relapsing-remitting form of multiple sclerosis. This drug also has been involved in research to manage lung complications in patients with COVID-19. Fingolimod binds to a range of sphingosine 1-phosphate receptors. It reduces the inflammation associated with multiple sclerosis due to suppressing the exit of lymphocytes from lymph nodes.

Formula: C₁₉H₃₃NO₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 307.47 g/mol

Ref: 3D-BF164460