CAS 162635-04-3

Temsirolimus

Description:

Temsirolimus is an antineoplastic agent primarily used in the treatment of renal cell carcinoma. It is a derivative of rapamycin and functions as an inhibitor of the mammalian target of rapamycin (mTOR), a key regulator of cell growth, proliferation, and survival. Temsirolimus is characterized by its ability to interfere with the signaling pathways that promote tumor growth, making it effective in certain types of cancer. The compound is typically administered intravenously and is known for its pharmacokinetic properties, including a relatively long half-life, which allows for sustained therapeutic effects. Its solubility profile is moderate, and it is often formulated with specific excipients to enhance its bioavailability. Common side effects associated with temsirolimus include fatigue, nausea, and potential immunosuppression, necessitating careful monitoring during treatment. Overall, temsirolimus represents a targeted therapeutic approach in oncology, particularly for patients with advanced renal cell carcinoma who may benefit from mTOR inhibition.

Formula: C₅₆H₈₇NO₁₆

InChI: InChI=1/C56H87NO16/c1-33-17-13-12-14-18-34(2)45(68-9)29-41-22-20-39(7)56(67,73-41)51(63)52(64)57-24-16-15-19-42(57)53(65)71-46(30-43(60)35(3)26-38(6)49(62)50(70-11)48(61)37(5)25-33)36(4)27-40-21-23-44(47(28-40)69-10)72-54(66)55(8,31-58)32-59/h12-14,17-18,26,33,35-37,39-42,44-47,49-50,58-59,62,67H,15-16,19-25,27-32H2,1-11H3/b14-12+,17-13+,34-18+,38-26+/t33-,35-,36-,37-,39-,40+,41+,42+,44-,45+,46+,47-,49-,50+,56-/m1/s1

InChI key: InChIKey=CBPNZQVSJQDFBE-FUXHJELOSA-N

SMILES: O=C1N2[C@](C(=O)O[C@]([C@@H](C[C@H]3C[C@@H](OC)[C@H](OC(C(CO)(CO)C)=O)CC3)C)(CC(=O)[C@H](C)/C=C(\C)/[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(/C)\[C@@H](OC)C[C@]4(O[C@@](O)(C1=O)[C@H](C)CC4)[H])[H])(CCCC2)[H]

Synonyms:

• (1R,2R,5S)-5-{(2S)-2-[(3S,6R,7E,9R,10R,12R,14S,15Z,17E,19E,21S,26R,27R,34aS)-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontin-3-yl]propyl}-2-methoxycyclohexyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate
• 4-{2-[(7E,15Z,17E,19E)-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontin-3-yl]propyl}-2-methoxycyclohexyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate
• 40-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate]-rapamycin
• Cci 779
• Ccl-779
• NSC 683864
• Rapamycin 42-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate
• Temsorolimus
• Torisel
• Way-Cci 779
• Temsirolimus

Temsirolimus

CAS: 162635-04-3

Formula: C₅₆H₈₇NO₁₆

Purity: >95.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 1,030.30

Ref: 3B-T3574

Temsirolimus

CAS: 162635-04-3

Formula: C₅₆H₈₇NO₁₆

Purity: 95%

Color and Shape: Solid

Molecular weight: 1030.2871

Ref: IN-DA00IML1

Temsirolimus

CAS: 162635-04-3

Formula: C₅₆H₈₇NO₁₆

Molecular weight: 1030.29

Ref: 7W-GK7650

Temsirolimus

CAS: 162635-04-3

Temsirolimus

Purity: 99%

Molecular weight: 1030.29g/mol

Ref: 54-OR1023896

Temsirolimus

CAS: 162635-04-3

Formula: C₅₆H₈₇NO₁₆

Color and Shape: White To Off-White Solid

Molecular weight: 1030.30

Ref: 4Z-T-118001

Temsirolimus

CAS: 162635-04-3

Temsirolimus

Purity: ≥95%

Molecular weight: 1030.29g/mol

Ref: 54-BUP05756

Temsirolimus

CAS: 162635-04-3

Temsirolimus (CCI-779) is a specific mTOR inhibitor ( IC50: 1.76 μM), used in the treatment of advanced renal cell cancer.

Formula: C₅₆H₈₇NO₁₆

Purity: 97.76% - >99.99%

Color and Shape: White Crystalline Powder

Molecular weight: 1030.29

Ref: TM-T2145

Temsirolimus-d3

Controlled Product

CAS: 162635-04-3

Applications Labelled ester analog of Rapamycin.
References Raymond, E., et al.: J. Clin. Oncol., 22, 2336 (2004), Galanis, E., et al.: J. Clin. Oncol., 23, 5294 (2005)

Formula: C₅₆H₈₄D₃NO₁₆

Purity: >85%

Color and Shape: Neat

Molecular weight: 1033.31

Ref: TR-T017962

Temsirolimus (~90%)

Controlled Product

CAS: 162635-04-3

Applications Ester analog of Rapamycin.
References Raymond, E., et al.: J. Clin. Oncol., 22, 2336 (2004), Galanis, E., et al.: J. Clin. Oncol., 23, 5294 (2005)

Formula: C₅₆H₈₇NO₁₆

Purity: >80%

Color and Shape: Neat

Molecular weight: 1030.29

Ref: TR-T017960

Temsirolimus

CAS: 162635-04-3

mTOR serine/threonine kinase inhibitor

Formula: C₅₆H₈₇NO₁₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,030.29 g/mol

Ref: 3D-FR61494

Temsirolimus-13C3,d7

Controlled Product

CAS: 162635-04-3

Formula: C₃C₅₃D₇H₈₀NO₁₆

Color and Shape: Neat

Molecular weight: 1040.308

Ref: TR-T017963