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CAS 162784-72-7

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7-Epi-10-oxo-docetaxel

Description:
7-Epi-10-oxo-docetaxel is a semi-synthetic derivative of the natural product taxol, which is known for its potent anticancer properties. This compound is characterized by its complex polycyclic structure, which includes a taxane core, and features a ketone functional group at the C10 position and an epimeric configuration at the C7 position. The presence of these functional groups contributes to its biological activity, particularly its ability to inhibit microtubule depolymerization, thereby disrupting mitotic processes in cancer cells. 7-Epi-10-oxo-docetaxel exhibits a high degree of lipophilicity, which influences its pharmacokinetics and bioavailability. It is typically administered in a formulation that enhances solubility and stability. The compound has been studied for its potential in treating various malignancies, including breast and lung cancers, and is part of ongoing research to improve therapeutic efficacy and reduce side effects compared to its parent compound, docetaxel. As with many chemotherapeutic agents, its use is associated with a range of potential side effects, necessitating careful monitoring during treatment.
Formula:C43H51NO14
Synonyms:
  • (2b,5b,7a,13a)-4-Acetoxy-13-(((2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl)oxy)-1,7-dihydroxy- 9,10-dioxo-5,20-epoxytax-11-en-2-yl Benzoate
  • Docetaxel Impurity D
  • 10-Oxo-7-Epi-Docetaxel
  • 7-Epi-10-Oxo-Docetaxel (Docetaxel Impurity D)
  • Docetaxel Impurity 4(Docetaxel EP Impurity D)
  • Docetaxel EP Impurity D/ 4-Epi-6-Oxo Docetaxel (10-Deoxy-10-Oxo-7-epi-Docetaxel)
  • Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4R,4aS,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5,6-dioxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
  • Docetaxel EP Impurity D
  • [(1S,2S,3R,4S,7R,9R,10S,15S)-4-acetyloxy-1,9-dihydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-10,14,17,17-tetramethyl-11,12-dioxo-6-oxatetracyclo[11.3.1.0^{3,10}.0^{4,7}]heptadec-13-en-2-yl] benzoate
  • Docetaxel EP Impurity D (7-epi-10-Oxo-Docetaxel)
  • See more synonyms
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