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CAS 162808-62-0

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Caspofungin

Description:
Caspofungin is an antifungal medication belonging to the echinocandin class, primarily used to treat invasive fungal infections, particularly those caused by Candida and Aspergillus species. It works by inhibiting the synthesis of β-(1,3)-D-glucan, an essential component of the fungal cell wall, thereby compromising the integrity of the cell wall and leading to cell lysis. Caspofungin is typically administered intravenously and is characterized by its stability in solution and low oral bioavailability, necessitating parenteral administration. The compound has a complex structure, featuring a cyclic hexapeptide backbone and a long-chain fatty acid side chain, which contribute to its antifungal activity and pharmacokinetic properties. It is generally well-tolerated, with side effects that may include fever, rash, and gastrointestinal disturbances. Caspofungin is particularly valuable in clinical settings for patients with compromised immune systems, such as those undergoing chemotherapy or organ transplantation, where the risk of opportunistic fungal infections is heightened.
Formula:C52H88N10O15
InChI:InChI=1/C52H88N10O15/c1-5-28(2)24-29(3)12-10-8-6-7-9-11-13-39(69)56-34-26-38(68)46(55-22-21-54)60-50(75)43-37(67)19-23-61(43)52(77)41(36(66)18-20-53)58-49(74)42(45(71)44(70)31-14-16-32(64)17-15-31)59-48(73)35-25-33(65)27-62(35)51(76)40(30(4)63)57-47(34)72/h14-17,28-30,33-38,40-46,55,63-68,70-71H,5-13,18-27,53-54H2,1-4H3,(H,56,69)(H,57,72)(H,58,74)(H,59,73)(H,60,75)/t28?,29?,30-,33-,34+,35+,36-,37+,38-,40?,41+,42?,43+,44+,45+,46-/m1/s1
Synonyms:
  • Caspofungine
  • Casporfungin
  • N-{(2R,9S,11R,12R,14aS,15S,20S,25aS)-12-[(2-aminoethyl)amino]-20-[(1R)-3-amino-1-hydroxypropyl]-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide
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