CAS 1628730-49-3

1,1,1,3,3,3-Hexafluoro-2-[[[5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(3-isoxazolyl)-1H-pyrazol-3-yl]-4-pyrimidinyl]amino]methyl]-2-propanol

Description:

1,1,1,3,3,3-Hexafluoro-2-[[[5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(3-isoxazolyl)-1H-pyrazol-3-yl]-4-pyrimidinyl]amino]methyl]-2-propanol, identified by its CAS number 1628730-49-3, is a complex organic compound characterized by its multiple fluorinated groups and a diverse molecular structure. The presence of hexafluoro groups imparts significant hydrophobicity and thermal stability, while the various functional groups, including a pyrazole and pyrimidine moiety, suggest potential biological activity, possibly as a pharmaceutical agent. This compound is likely to exhibit unique solubility properties due to its fluorinated nature, which can influence its interaction with biological membranes. Additionally, the intricate arrangement of substituents may contribute to its reactivity and potential applications in medicinal chemistry. Overall, this substance represents a sophisticated example of modern synthetic organic chemistry, with implications for drug development and material science.

Formula: C₂₁H₁₄F₈N₆O₂

InChI: InChI=1S/C21H14F8N6O2/c22-12-4-2-1-3-11(12)9-35-16(14-5-6-37-34-14)7-15(33-35)18-30-8-13(23)17(32-18)31-10-19(36,20(24,25)26)21(27,28)29/h1-8,36H,9-10H2,(H,30,31,32)

InChI key: InChIKey=CYSJNTQNMDWAJV-UHFFFAOYSA-N

SMILES: C(N1C(=CC(=N1)C=2N=C(NCC(C(F)(F)F)(C(F)(F)F)O)C(F)=CN2)C=3C=CON3)C4=C(F)C=CC=C4

Synonyms:

• IW 1973
• 1,1,1,3,3,3-hexafluoro-2-{[(5-fluoro-2-{1-[(2-fluorophenyl)methyl]-5-(1,2-oxazol-3-yl)-1H-pyrazol-3-yl}pyrimidin-4-yl)amino]methyl}propan-2-ol
• 1,1,1,3,3,3-Hexafluoro-2-[[[5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(3-isoxazolyl)-1H-pyrazol-3-yl]-4-pyrimidinyl]amino]methyl]-2-propanol
• Praliciguat
• 2-Propanol, 1,1,1,3,3,3-hexafluoro-2-[[[5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(3-isoxazolyl)-1H-pyrazol-3-yl]-4-pyrimidinyl]amino]methyl]-
• Praliciguat,IW 1973,Guanylate Cyclase,Inhibitor,IW1973,inhibit

Praliciguat

CAS: 1628730-49-3

Praliciguat

Purity: ≥98%

Molecular weight: 534.36g/mol

Ref: 54-BUP05087

Praliciguat

CAS: 1628730-49-3

Praliciguat (IW-1973) is an orally active sGC stimulator with a 197 nM EC50 in HEK-293 cells, enhances NO signaling, and is a vasodilator.

Formula: C₂₁H₁₄F₈N₆O₂

Purity: 98.82%

Color and Shape: Solid

Molecular weight: 534.36

Ref: TM-T16569

Praliciguat

CAS: 1628730-49-3

Formula: C₂₁H₁₄F₈N₆O₂

Molecular weight: 534.37

Ref: 4Z-P-326001

Praliciguat-d6

CAS: 1628730-49-3

Formula: C₂₁H₈D₆F₈N₆O₂

Molecular weight: 540.41

Ref: 4Z-P-326002

Praliciguat

CAS: 1628730-49-3

Praliciguat is a drug that has the potential to be used in the treatment of chronic pulmonary diseases. It is a soluble guanylate cyclase (sGC) stimulator, which can promote the release of nitric oxide from endothelial cells. Praliciguat also increases insulin sensitivity and improves cardiac function in patients with chronic heart failure. This drug has been shown to have beneficial effects on hepatic steatosis and insulin resistance in experimental animals. Praliciguat has also been shown to improve insulin sensitivity, reduce inflammation, and inhibit viral replication in animal models of type 1 diabetes.

Formula: C₂₁H₁₄F₈N₆O₂

Purity: Min. 95%

Molecular weight: 534.36 g/mol

Ref: 3D-BP177758