CAS 16289-13-7

Chlorthalidone Impurity G

Description:

Chlorthalidone Impurity G, with the CAS number 16289-13-7, is a chemical compound that is recognized as an impurity associated with the thiazide diuretic chlorthalidone. This substance is typically characterized by its structural similarity to chlorthalidone, which is a sulfonamide derivative. Impurity G may exhibit properties such as solubility in organic solvents and varying stability under different pH conditions. Its presence in pharmaceutical formulations is of concern due to potential impacts on the efficacy and safety of the final product. Analytical methods, such as high-performance liquid chromatography (HPLC), are commonly employed to detect and quantify this impurity in drug formulations. Regulatory guidelines often dictate acceptable limits for impurities to ensure product quality. Understanding the characteristics of Chlorthalidone Impurity G is essential for pharmaceutical development and quality control, as it helps in assessing the purity of chlorthalidone and ensuring compliance with safety standards.

Formula: C₁₄H₉Cl₂NO₂

InChI: InChI=1/C14H9Cl2NO2/c15-11-6-5-8(7-12(11)16)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)

SMILES: c1ccc2c(c1)C(=NC2(c1ccc(c(c1)Cl)Cl)O)O

Synonyms:

• 3-(3,4-Dichlorophenyl)-3-hydroxy-phthalimidin
• (3-(3,4-Dichlorophenyl)-3-hydroxy-phthalimidine)

Dichloro Chlorthalidone (3-(3,4-Dichlorophenyl)-3-hydroxyisoindolin-1-one)

CAS: 16289-13-7

Lactams, nesoi

Formula: C₁₄H₉Cl₂NO₂

Color and Shape: Off-White Powder

Molecular weight: 293.00103

Ref: 45-1A11030

Chlorthalidone Impurity G

CAS: 16289-13-7

Formula: C₁₄H₉Cl₂NO₂

Color and Shape: Solid

Molecular weight: 294.1328

Ref: IN-DA001TJ1

Chlortalidone (Chlorthalidone) EP Impurity G

CAS: 16289-13-7

Formula: C₁₄H₉Cl₂NO₂

Color and Shape: White To Off-White Solid

Molecular weight: 294.13

Ref: 4Z-C-140002

Chlorthalidone Impurity G

CAS: 16289-13-7

Chlorthalidone impurity G, a thiazide-like diuretic's contaminant, has mild antihypertensive properties and inhibits several carbonic anhydrase isoforms.

Formula: C₁₄H₉Cl₂NO₂

Color and Shape: Solid

Molecular weight: 294.13

Ref: TM-T35876

Chlortalidone EP impurity G

CAS: 16289-13-7

Formula: C₁₄H₉Cl₂NO₂

Molecular weight: 294.13

Ref: ST-EA-CP-C20007

Chloro Chlorthalidone

Controlled Product

CAS: 16289-13-7

Formula: C₁₄H₉Cl₂NO₂

Color and Shape: Neat

Molecular weight: 294.13

Ref: TR-C427520

Chlorthalidone impurity G

CAS: 16289-13-7

Chlorthalidone impurity G is a synthetic, high purity, pharmacopoeia grade impurity standard for chlorthalidone. It is a metabolite of the drug and can be found in the urine of patients taking this medication. Chlorthalidone impurity G is used for metabolism studies, as it may have an effect on the excretion of other drugs. Research and Development

Formula: C₁₄H₉Cl₂NO₂

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 294.13 g/mol

Ref: 3D-IC20415