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CAS 163133-43-5

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Naproxcinod

Description:
Naproxcinod is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the class of compounds known as cinod compounds, which are designed to provide anti-inflammatory effects while minimizing gastrointestinal side effects commonly associated with traditional NSAIDs. It is characterized by its dual mechanism of action, functioning as both a cyclooxygenase (COX) inhibitor and a nitric oxide donor, which may enhance its therapeutic efficacy and reduce the risk of gastrointestinal complications. Naproxcinod is primarily used for the management of pain and inflammation associated with conditions such as osteoarthritis and rheumatoid arthritis. Its pharmacokinetics involve absorption after oral administration, with metabolism occurring primarily in the liver. The compound is known for its relatively favorable safety profile compared to other NSAIDs, although it may still present risks such as cardiovascular effects and potential interactions with other medications. Overall, Naproxcinod represents an innovative approach in the development of anti-inflammatory therapies, aiming to balance efficacy with safety.
Formula:C18H21NO6
InChI:InChI=1S/C18H21NO6/c1-13(18(20)24-9-3-4-10-25-19(21)22)14-5-6-16-12-17(23-2)8-7-15(16)11-14/h5-8,11-13H,3-4,9-10H2,1-2H3/t13-/m0/s1
InChI key:InChIKey=AKFJWRDCWYYTIG-ZDUSSCGKSA-N
SMILES:[C@H](C(OCCCCON(=O)=O)=O)(C)C1=CC2=C(C=C(OC)C=C2)C=C1
Synonyms:
  • HCT 3012
  • 2-Naphthaleneacetic acid, 6-methoxy-α-methyl-, 4-(nitrooxy)butyl ester, (S)-
  • (S)-2-(6-Methoxy-2-naphthyl)propanoic acid 4-nitrooxybutyl ester
  • 2-Naphthaleneacetic acid, 6-methoxy-α-methyl-, 4-(nitrooxy)butyl ester, (αS)-
  • Nitronaproxen
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