CAS 163163-23-3

rel-N-[(3R,4S)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methylethanesulfonamide

Description:

The chemical substance known as rel-N-[(3R,4S)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methylethanesulfonamide, with the CAS number 163163-23-3, is characterized by its complex molecular structure, which includes a benzopyran core, a cyano group, and a sulfonamide moiety. This compound exhibits properties typical of sulfonamides, such as potential antibacterial activity, although its specific biological activity may vary. The presence of the cyano and hydroxy groups suggests it may participate in various chemical reactions, including nucleophilic substitutions or hydrogen bonding interactions. The stereochemistry indicated by the (3R,4S) configuration suggests that the compound may exhibit chirality, which can influence its pharmacological properties and interactions with biological targets. Additionally, the presence of the dimethyl group contributes to its lipophilicity, potentially affecting its solubility and permeability in biological systems. Overall, this compound's unique structural features may confer specific therapeutic applications, warranting further investigation into its biological effects and mechanisms of action.

Formula: C₁₅H₂₀N₂O₄S

InChI: InChI=1/C15H20N2O4S/c1-5-22(19,20)17(4)13-11-8-10(9-16)6-7-12(11)21-15(2,3)14(13)18/h6-8,13-14,18H,5H2,1-4H3/t13-,14-/m1/s1

InChI key: InChIKey=HVSJHHXUORMCGK-DUXBJXIBNA-N

SMILES: N(S(CC)(=O)=O)(C)[C@H]1C=2C(OC(C)(C)[C@@H]1O)=CC=C(C#N)C2

Synonyms:

• 6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane
• Chromanol 239B
• Ethanesulfonamide, N-(6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl)-N-methyl-, trans-
• Ethanesulfonamide, N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-, rel-
• N-(6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl)-N-methylethanesulfonamide
• N-[(3R,4R)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl]-N-methylethanesulfonamide
• N-[(3R,4S)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl]-N-methylethanesulfonamide
• Trans-N-[6-Cyano-3,4-Dihydro-3-Hydroxy-2,2-Dimethyl-2H-1-Benzopyran-4-Yl]-N-Methyl-Ethanesulfonamide
• rel-N-[(3R,4S)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methylethanesulfonamide
• 293B
• CHROMANOL 293B
• Chromanol 293B >=98% (HPLC), powder
• N-[(3R,4S)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamide

Ethanesulfonamide, N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-, rel-

CAS: 163163-23-3

Formula: C₁₅H₂₀N₂O₄S

Molecular weight: 324.3953

Ref: IN-DA001TT9

Chromanol 293B

CAS: 163163-23-3

Formula: C₁₅H₂₀N₂O₄S

Molecular weight: 324.40

Ref: 7W-GK2240

Chromagnol

CAS: 163163-23-3

Chromagnol is a drug that inhibits the enzyme protein kinase C (PKC). It has been shown to have inhibitory properties on cardiac muscle cells and whole-cell recordings of heart cells. Chromagnol has also been shown to affect the function of bowel disease, including papillary muscle. Chromagnol has been shown to have effects on cardiac and atrial tissue. This drug may be a potential treatment for autoimmune diseases, such as multiple sclerosis, or other diseases that are caused by PKC overactivity. The mechanisms of action are not fully understood but it is believed that chromanol binds to the cytosolic Ca2+ ion channel, preventing it from opening and releasing Ca2+, which leads to an increase in intracellular Ca2+.

Formula: C₁₅H₂₀N₂O₄S

Purity: Min. 95%

Molecular weight: 324.4 g/mol

Ref: 3D-FC166930

Chromanol 293B

CAS: 163163-23-3

Chromanol 293B, Cardiac IK and CFTR chloride current inhibitor (IC50=1-19 μM), weak KATP channel blocker, for arrhythmia research.

Formula: C₁₅H₂₀N₂O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 324.4

Ref: TM-T22662