CAS 16320-04-0

Gestrinone

Description:

Gestrinone is a synthetic steroid with progestational and antiestrogenic properties, primarily used in the treatment of endometriosis and other gynecological disorders. It is classified as a synthetic derivative of testosterone and exhibits a unique mechanism of action by modulating hormonal pathways. Gestrinone functions by inhibiting the secretion of gonadotropins, which in turn reduces estrogen levels, thereby alleviating symptoms associated with estrogen-dependent conditions. The compound is typically administered orally and is characterized by its lipophilic nature, allowing for effective absorption and distribution in the body. Its chemical structure includes a cyclopentene ring, contributing to its biological activity. While Gestrinone is effective in managing certain medical conditions, it may also have side effects, including hormonal imbalances and potential impacts on liver function. As with any medication, its use should be closely monitored by healthcare professionals to ensure safety and efficacy. Overall, Gestrinone represents a significant option in the pharmacological management of specific reproductive health issues.

Formula: C₂₁H₂₄O₂

InChI: InChI=1S/C21H24O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,9,11,13,18-19,23H,3,5-8,10,12H2,1H3/t18-,19+,20+,21+/m1/s1

InChI key: InChIKey=BJJXHLWLUDYTGC-ANULTFPQSA-N

SMILES: C(C)[C@@]12[C@]([C@]3(C(C=C1)=C4C(CC3)=CC(=O)CC4)[H])(CC[C@]2(C#C)O)[H]

Synonyms:

• (17α)-13-Ethyl-17-hydroxy-18,19-dinorpregna-4,9,11-trien-20-yn-3-one
• (8S,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-3-one (non-preferred name)
• 13-Ethyl-17-alpha-ethinyl-17-hydroxygon-4,9,11-trien-3-one
• 13-Ethyl-17-hydroxy-18,19-dinor-17alpha-pregna-4,9,11-trien-20-yn-3-one
• 13-Ethyl-17α-ethynyl-17β-hydroxygona-4,9,11-trien-3-one
• 13-beta-Ethyl-17-alpha-ethinyl-17-hydroxy-gona-4,9,11-triene-3-one
• 18,19-Dinor-17-alpha-pregna-4,9,11-trien-20-yn-3-one, 13-ethyl-17-hydroxy-
• 18,19-Dinor-17α-pregna-4,9,11-trien-20-yn-3-one, 13-ethyl-17-hydroxy-
• 18,19-Dinorpregna-4,9,11-trien-20-yn-3-one, 13-ethyl-17-hydroxy-, (17-alpha)- (9CI)
• 18,19-Dinorpregna-4,9,11-trien-20-yn-3-one, 13-ethyl-17-hydroxy-, (17α)-
• A 46745
• Brn 5610726
• Dimetriose
• Dimetrose
• Ethylnorgestrienone
• Gestrigone
• Gestrinona
• Gestrinona [INN-Spanish]
• Gestrinone [USAN:INN:BAN]
• Gestrinonum
• Gestrinonum [INN-Latin]
• Nemestran
• Pregna-4,9,11-trien-20-yn-3-one, 13-ethyl-17-hydroxy-18,19-dinor-, (17alpha)-
• R-2323
• Ru 2323
• Tridomose
• Unii-1421533Rcm

Gestrinone

CAS: 16320-04-0

Gestrinone (R 2323) 是一种合成类固醇激素，能够抑制平滑肌瘤(IC50:43.67 μM)，有用于子宫内膜异位症的研究潜力。

Formula: C₂₁H₂₄O₂

Purity: 99.21%

Color and Shape: Light Yellow Solid

Molecular weight: 308.41

Ref: TM-T7223

Gestrinone

CAS: 16320-04-0

Formula: C₂₁H₂₄O₂

Molecular weight: 308.41

Ref: 7W-GP4139

Gestrinone

CAS: 16320-04-0

Formula: C₂₁H₂₄O₂

Purity: >98.0%(T)

Color and Shape: Light yellow to Yellow powder to crystal

Molecular weight: 308.42

Ref: 3B-G0436

Gestrinone

Controlled Product

CAS: 16320-04-0

Applications Gestrinone is a Steroidal antiestrogen, antiprogestogen, analog of Norgestrienone. Antigonadotropin.Controlled substance.
References Azadian-Boulanger, G., et al.: Am. J. Obstet. Gynecol., 125, 1049 (1976), Thomas, E.J., et al.: Br. Med. J., 294, 272 (1987), Coutinho, E.M., et al.: Fertil. Steril., 49, 418 (1988),

Formula: C₂₁H₂₄O₂

Color and Shape: Neat

Molecular weight: 308.40

Ref: TR-G368800

6α-Hydroxy Gestrinone Glucuronide

Controlled Product

CAS: 16320-04-0

Formula: C₂₇H₃₂O₉

Color and Shape: Light Yellow

Molecular weight: 500.54

Ref: TR-H942803

Gestrinone-d3 (major)

Controlled Product

CAS: 16320-04-0

Formula: C₂₁D₃H₂₁O₂

Color and Shape: Neat

Molecular weight: 311.433

Ref: TR-G368802

Gestrinone (1 mg/ml in Acetonitrile)

Controlled Product

CAS: 16320-04-0

Formula: C₂₁H₂₄O₂

Color and Shape: Single Solution

Molecular weight: 308.40

Ref: TR-KIT4830

Gestrinone

Controlled Product

CAS: 16320-04-0

Gestrinone is a synthetic steroidal hormone that binds to the progesterone receptor. It has been used in the treatment of endometriosis, although its efficacy is questionable. Gestrinone is a potent inhibitor of cyclooxygenase and lipoxygenase, which leads to an anti-inflammatory effect. Gestrinone also suppresses gonadotropin secretion from the pituitary gland by reducing gonadotropin-releasing hormone (GnRH) release. The drug has been found to have contraceptive activity in vivo and in vitro, but it does not appear to inhibit ovulation or fertilization. Gestrinone inhibits estrogen synthesis by blocking the conversion of estradiol benzoate into estradiol during pregnancy. This drug also inhibits aromatase activity and has been shown to be effective against endometriosis in humans. However, gestrinone is associated with side effects such as nausea, breast tenderness, weight gain, headache, depression and fatigue

Formula: C₂₁H₂₄O₂

Purity: Min. 95%

Molecular weight: 308.41 g/mol

Ref: 3D-FG156783

Gestrinone

CAS: 16320-04-0

Formula: C₂₁H₂₄O₂

Molecular weight: 308.42

Ref: ST-EA-CP-G21023

18,19-Dinorpregna-4,9,11-trien-20-yn-3-one, 13-ethyl-17-hydroxy-, (17α)-

CAS: 16320-04-0

Formula: C₂₁H₂₄O₂

Purity: 99%

Color and Shape: Solid

Molecular weight: 308.4141

Ref: IN-DA001TUP