CAS 163217-70-7

(2R-trans)-5-(4-Fluorophenyl)-2-(1-methylethyl)-N-(4-hydroxyphenyl)-4-phenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-ethyl]-1H-pyrrole-3-carboxamide

Description:

The chemical substance with the name "(2R-trans)-5-(4-Fluorophenyl)-2-(1-methylethyl)-N-(4-hydroxyphenyl)-4-phenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-ethyl]-1H-pyrrole-3-carboxamide" and CAS number "163217-70-7" is a complex organic compound characterized by its multi-ring structure and various functional groups. It features a pyrrole ring, which is a five-membered aromatic heterocycle, and incorporates a carboxamide functional group, indicating potential for hydrogen bonding and interactions with biological targets. The presence of a fluorophenyl group suggests enhanced lipophilicity and potential for increased biological activity. Additionally, the compound contains hydroxy groups, which can contribute to solubility and reactivity. Its stereochemistry, indicated by the (2R-trans) configuration, may influence its pharmacological properties and interactions with biological systems. Overall, this compound is likely to be of interest in medicinal chemistry, particularly in the development of pharmaceuticals targeting specific biological pathways.

Formula: C₃₃H₃₃FN₂O₅

InChI: InChI=1S/C33H33FN2O5/c1-20(2)31-30(33(40)35-24-12-14-25(37)15-13-24)29(21-6-4-3-5-7-21)32(22-8-10-23(34)11-9-22)36(31)17-16-27-18-26(38)19-28(39)41-27/h3-15,20,26-27,37-38H,16-19H2,1-2H3,(H,35,40)/t26-,27-/m1/s1

InChI key: InChIKey=KDJMDZSAAFACAM-KAYWLYCHSA-N

SMILES: C(NC1=CC=C(O)C=C1)(=O)C=2C(=C(N(CC[C@@H]3C[C@@H](O)CC(=O)O3)C2C(C)C)C4=CC=C(F)C=C4)C5=CC=CC=C5

Synonyms:

• 1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-N-(4-hydroxyphenyl)-2-(1-methylethyl)-4-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-
• 5-(4-Fluorophenyl)-N-(4-hydroxyphenyl)-2-(1-methylethyl)-4-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide
• 1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-N-(4-hydroxyphenyl)-2-(1-methylethyl)-4-phenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-, (2R-trans)-
• (2R-trans)-5-(4-Fluorophenyl)-2-(1-methylethyl)-N-(4-hydroxyphenyl)-4-phenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-ethyl]-1H-pyrrole-3-carboxamide

4-hydroxy Atorvastatin lactone

CAS: 163217-70-7

Formula: C₃₃H₃₃FN₂O₅

Color and Shape: Solid

Molecular weight: 556.6239

Ref: IN-DA001TVB

para-Hydroxy Atorvastatin Lactone

CAS: 163217-70-7

Formula: C₃₃H₃₃FN₂O₅

Color and Shape: White To Off-White Solid

Molecular weight: 556.63

Ref: 4Z-A-128

4-Hydroxy atorvastatin lactone

CAS: 163217-70-7

4-Hydroxy atorvastatin lactone is a prodrug that can be hydrolyzed to the active form, atorvastatin. It is an inhibitor of HMG-CoA reductase and has been shown to significantly lower cholesterol levels in humans. 4-Hydroxy atorvastatin lactone has been shown to have no significant drug interactions with other drugs metabolized by cytochrome P450 3A5 (CYP3A5). A pharmacokinetic study of healthy Chinese subjects showed that plasma concentrations of 4-hydroxy atorvastatin lactone increased with increasing doses. Linear ranges were observed for human liver validation studies. Pharmacokinetic parameters were determined using chromatographic science, including linearity, limit of detection, limit of quantification, and specificity. The validation study was completed using electrospray ionization mass spectrometry.

Formula: C₃₃H₃₃FN₂O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 556.62 g/mol

Ref: 3D-FH23909

Atorvastatin 4-Hydroxy Lactone

CAS: 163217-70-7

Formula: C₃₃H₃₃FN₂O₅

Molecular weight: 556.63

Ref: ST-EA-CP-A32057