CAS 163217-74-1

O-HYDROXY ATORVASTATIN LACTONE

Description:

O-Hydroxy Atorvastatin Lactone is a derivative of atorvastatin, a widely used statin for lowering cholesterol levels. This compound is characterized by its lactone structure, which is formed through the cyclization of the carboxylic acid group present in atorvastatin. It exhibits a high degree of lipophilicity, allowing it to effectively penetrate cell membranes and exert its pharmacological effects. The compound functions primarily as an HMG-CoA reductase inhibitor, which plays a crucial role in cholesterol biosynthesis. Its mechanism of action involves the inhibition of the enzyme responsible for converting HMG-CoA to mevalonate, a precursor in the cholesterol synthesis pathway. Additionally, O-Hydroxy Atorvastatin Lactone may possess antioxidant properties and contribute to the stabilization of atherosclerotic plaques. The compound is typically administered in its active form, and its pharmacokinetics can be influenced by factors such as metabolism and excretion. Overall, O-Hydroxy Atorvastatin Lactone represents an important aspect of cardiovascular pharmacotherapy, with ongoing research exploring its full therapeutic potential and safety profile.

Formula: C₃₃H₃₃FN₂O₅

1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-N-(2-hydroxyphenyl)-2-(1-methylethyl)-4-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-

CAS: 163217-74-1

Formula: C₃₃H₃₃FN₂O₅

Color and Shape: Solid

Molecular weight: 556.6239

Ref: IN-DA001TVA

2-Hydroxy atorvastatin lactone

CAS: 163217-74-1

2-Hydroxy atorvastatin lactone

Purity: 98%

Molecular weight: 556.62g/mol

Ref: 54-PC1008075

ortho-Hydroxy Atorvastatin Lactone

CAS: 163217-74-1

Formula: C₃₃H₃₃FN₂O₅

Color and Shape: White To Off-White Solid

Molecular weight: 556.63

Ref: 4Z-A-129

2-Hydroxy atorvastatin lactone

CAS: 163217-74-1

2-Hydroxy atorvastatin lactone, a metabolite of Atorvastatin, is an orally active HMG-CoA reductase inhibitor that efficiently reduces blood lipids [1][2].

Formula: C₃₃H₃₃FN₂O₅

Color and Shape: Solid

Molecular weight: 556.62

Ref: TM-T38249

Ascorbic Acid Impurity 12

CAS: 163217-74-1

Formula: C₆H₉ClO₅

Color and Shape: White To Off-White Solid

Molecular weight: 196.58

Ref: 4Z-A-129027

2-Hydroxy atorvastatin lactone

CAS: 163217-74-1

2-Hydroxyatorvastatin lactone is a prodrug of atorvastatin, which is an HMG-CoA reductase inhibitor. It is used to lower cholesterol and triglycerides in the blood. The drug is administered as a tablet, capsule, or liquid and can be taken with or without food. 2-Hydroxyatorvastatin lactone is metabolized by cytochrome P450 enzymes in the liver to produce active atorvastatin. This metabolism may be inhibited by other drugs that are also metabolized by cytochrome P450 enzymes, such as erythromycin and ketoconazole. 2-Hydroxyatorvastatin lactone has been shown to have an inhibition constant (Ki) of 0.5 μM for human liver microsomes and plasma concentrations of 1 μM or higher are required for therapeutic effect.

Formula: C₃₃H₃₃FN₂O₅

Purity: Min. 95%

Color and Shape: Off-White Slightly Yellow Powder

Molecular weight: 556.62 g/mol

Ref: 3D-FH23908

2-Hydroxy Atorvastatin Lactone

Controlled Product

CAS: 163217-74-1

Impurity Atorvastatin 2-Hydroxy Lactone
Stability Hygroscopic
Applications A metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.

Formula: C₃₃H₃₃FN₂O₅

Color and Shape: Off White Solid

Molecular weight: 556.62

Ref: TR-H828955

Atorvastatin 2-Hydroxy Lactone

CAS: 163217-74-1

Formula: C₃₃H₃₃FN₂₀₅

Molecular weight: 556.63

Ref: ST-EA-CP-A32052