CAS 163222-33-1

Ezetimibe

Description:

Ezetimibe is a pharmaceutical compound primarily used to lower cholesterol levels in patients with hyperlipidemia. It functions by inhibiting the absorption of cholesterol at the intestinal brush border, thereby reducing the amount of cholesterol that enters the bloodstream. Ezetimibe is often prescribed in conjunction with statins to enhance lipid-lowering effects. The substance has a molecular formula of C24H21F2N3O3 and a molecular weight of approximately 409.44 g/mol. It is characterized by its white to off-white crystalline powder form, which is practically insoluble in water but soluble in organic solvents like methanol and ethanol. Ezetimibe is typically administered orally and has a half-life that allows for once-daily dosing. Its safety profile is generally favorable, with common side effects including gastrointestinal disturbances. The compound is marketed under various brand names and is included in treatment regimens for cardiovascular disease prevention. Overall, Ezetimibe represents a significant advancement in cholesterol management, particularly for patients who are statin-intolerant or require additional lipid-lowering therapy.

Formula: C₂₄H₂₁F₂NO₃

InChI: InChI=1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1

InChI key: InChIKey=OLNTVTPDXPETLC-XPWALMASSA-N

SMILES: C(C[C@H](O)C1=CC=C(F)C=C1)[C@@H]2[C@H](N(C2=O)C3=CC=C(F)C=C3)C4=CC=C(O)C=C4

Synonyms:

• (-)-Sch 58235
• (3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone
• (3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone, Sch-58235
• (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one
• 1-(4-Fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)azetidin-2-one
• 1-(4-Fluorophenyl)-3-[3-(4-Fluorophenyl)-3-Hydroxy-Propyl]-4-(4-Hydroxyphenyl)-Azetidin-2-One
• 1-(4-Flurophenyl)-(3R)-3-(4-flurophenyl)-(3S)-hydroxypropyl-(4S)-(4-hydroxyphenyl)-2-azetidinone
• 2-Azetidinone, 1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-, (3R,4S)-
• 2-Azetidinone, 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-, [3R-[3α(S*),4β]]-
• Ezedoc
• Ezentia
• EzetimibeC24H21F2N03
• Ezetimide
• Ezetrol
• Ezitimibe&Int
• Zetia
• Ezitimibe∬ EzetimibeC24H21F2N03

Ezetimibe

CAS: 163222-33-1

Formula: C₂₄H₂₁F₂NO₃

Purity: >95.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 409.43

Ref: 3B-E1449

Ezetimibe

CAS: 163222-33-1

Lactams, nesoi

Formula: C₂₄H₂₁F₂NO₃

Color and Shape: White Powder

Molecular weight: 409.14895

Ref: 45-1269028

2-Azetidinone, 1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-, (3R,4S)-

CAS: 163222-33-1

Formula: C₂₄H₂₁F₂NO₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 409.4252

Ref: IN-DA001TWG

Ezetimibe

CAS: 163222-33-1

Ezetimibe (SCH 58235) is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption.

Formula: C₂₄H₂₁F₂NO₃

Purity: 97.28% - 99.77%

Color and Shape: Solid

Molecular weight: 409.43

Ref: TM-T1593

Ezetimibe

CAS: 163222-33-1

Formula: C₂₄H₂₁F₂NO₃

Color and Shape: White To Off-White Solid

Molecular weight: 409.43

Ref: 4Z-E-064

Ezetimibe

CAS: 163222-33-1

Ezetimibe

Purity: ≥95%

Molecular weight: 409.43g/mol

Ref: 54-BUP17161

Ezetimibe

CAS: 163222-33-1

Ezetimibe

Purity: 99%

Molecular weight: 409.43g/mol

Ref: 54-PC109213

Ezetimibe

CAS: 163222-33-1

Formula: C₂₄H₂₁F₂NO₃

Purity: ≥ 98.0%

Color and Shape: White to almost white powder

Molecular weight: 409.43

Ref: 7W-GP8120

Ezetimibe

CAS: 163222-33-1

Color and Shape: Neat

Ref: 86-MM0935.00

Ezetimibe

CAS: 163222-33-1

Purity: 95%+

Molecular weight: 409.433013916016

Ref: 10-F861992

Ezetimibe

CAS: 163222-33-1

Formula: C₂₄H₂₁F₂NO₃

Color and Shape: Neat

Molecular weight: 409.43

Ref: TR-E975000

Ezetimibe

CAS: 163222-33-1

Inhibitor of cholesterol transporter NPC1L1

Formula: C₂₄H₂₁F₂NO₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 409.43 g/mol

Ref: 3D-FE23215

Ezetimibe - Bio-X ™

CAS: 163222-33-1

Ezetimibe is a lipid-lowering compound that inhibits cholesterol absorption. This drug helps to lower cholesterol in primary hyperlipidemia and familial cholesterolemia. Ezetimibe targets the cholesterol transport protein Niemann-Pick C1-Like 1 (NPC1L1).

Formula: C₂₄H₂₁F₂NO₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 409.43 g/mol

Ref: 3D-BE164439

(3R,4S)-1-(4-Fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one, Ezetimibe Impurity

CAS: 163222-33-1

Purity: 98%

Molecular weight: 409.15

Ref: 10-F567596

3'-Dehydroxy-1,2-seco Ezetimibe Sodium Salt

Controlled Product

CAS: 163222-33-1

Formula: C₂₄H₂₂F₂NNaO₃

Color and Shape: Neat

Molecular weight: 433.423

Ref: TR-D297558