CymitQuimica logo

CAS 163222-33-1

:

Ezetimibe

Description:
Ezetimibe is a pharmaceutical compound primarily used to lower cholesterol levels in patients with hyperlipidemia. It functions by inhibiting the absorption of cholesterol at the intestinal brush border, thereby reducing the amount of cholesterol that enters the bloodstream. Ezetimibe is often prescribed in conjunction with statins to enhance lipid-lowering effects. The substance has a molecular formula of C24H21F2N3O3 and a molecular weight of approximately 409.44 g/mol. It is characterized by its white to off-white crystalline powder form, which is practically insoluble in water but soluble in organic solvents like methanol and ethanol. Ezetimibe is typically administered orally and has a half-life that allows for once-daily dosing. Its safety profile is generally favorable, with common side effects including gastrointestinal disturbances. The compound is marketed under various brand names and is included in treatment regimens for cardiovascular disease prevention. Overall, Ezetimibe represents a significant advancement in cholesterol management, particularly for patients who are statin-intolerant or require additional lipid-lowering therapy.
Formula:C24H21F2NO3
InChI:InChI=1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1
InChI key:InChIKey=OLNTVTPDXPETLC-XPWALMASSA-N
SMILES:C(C[C@H](O)C1=CC=C(F)C=C1)[C@@H]2[C@H](N(C2=O)C3=CC=C(F)C=C3)C4=CC=C(O)C=C4
Synonyms:
  • (-)-Sch 58235
  • (3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone
  • (3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone, Sch-58235
  • (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one
  • 1-(4-Fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)azetidin-2-one
  • 1-(4-Fluorophenyl)-3-[3-(4-Fluorophenyl)-3-Hydroxy-Propyl]-4-(4-Hydroxyphenyl)-Azetidin-2-One
  • 1-(4-Flurophenyl)-(3R)-3-(4-flurophenyl)-(3S)-hydroxypropyl-(4S)-(4-hydroxyphenyl)-2-azetidinone
  • 2-Azetidinone, 1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-, (3R,4S)-
  • 2-Azetidinone, 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-, [3R-[3α(S*),4β]]-
  • Ezedoc
  • See more synonyms
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 18 products.