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CAS 163254-40-8

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Disodium folinate

Description:
Disodium folinate, also known as leucovorin, is a water-soluble compound that serves as a reduced form of folic acid. It is characterized by its ability to enhance the efficacy of certain chemotherapeutic agents, particularly in the treatment of cancer, by providing a source of folate that can bypass metabolic blockages caused by drugs like methotrexate. This compound is typically presented as a white to off-white powder and is highly soluble in water, making it suitable for intravenous or oral administration. Disodium folinate is often used in clinical settings to mitigate the toxic effects of folate antagonists and to support normal cellular function during chemotherapy. Its mechanism of action involves the conversion to active folate forms, which are essential for DNA synthesis and repair. Additionally, it is important to note that disodium folinate should be used under medical supervision, as its administration requires careful consideration of the patient's overall treatment plan and potential interactions with other medications.
Formula:C20H21N7Na2O7
InChI:InChI=1/C20H23N7O7.2Na/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);;/q;2*+1/p-2/t12-,13-;;/m0../s1
SMILES:c1cc(ccc1C(=O)NC(CCC(=O)O)C(=O)O)NCC1CNc2c(c(nc(=N)[nH]2)O)N1C=O.[Na].[Na]
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