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CAS 163380-16-3

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(3'R)-Ezetimibe

Description:
(3'R)-Ezetimibe is a selective cholesterol absorption inhibitor primarily used in the management of hyperlipidemia. It functions by blocking the intestinal absorption of cholesterol, thereby reducing the amount of cholesterol that enters the bloodstream. This compound is characterized by its specific stereochemistry, with the (3'R) designation indicating the configuration at a particular chiral center, which is crucial for its biological activity. Ezetimibe is often used in combination with statins to enhance lipid-lowering effects. The substance is typically administered orally and is well-absorbed in the gastrointestinal tract, although its bioavailability is influenced by factors such as food intake. Ezetimibe is metabolized in the liver, and its active metabolite contributes to its pharmacological effects. Common side effects may include gastrointestinal disturbances, but it is generally well-tolerated. The compound's efficacy in lowering LDL cholesterol levels has made it a valuable option in cardiovascular risk management. Overall, (3'R)-Ezetimibe represents a significant advancement in lipid-lowering therapies.
Formula:C24H21F2NO3
Synonyms:
  • (3R,4S)-1-(4-Fluorophenyl)-3-[(3R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone ((3'R)-Ezetimibe)
  • 2-Azetidinone, 1-(4-fluorophenyl)-3-[(3R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-, (3R,4S)-
  • RRS-Ezetimibe Q: What is the storage condition of
  • Ezetimibe impurities 4
  • EzetiMibe (3R)-IsoMer
  • Ezetimibe-23
  • (3’R)-Ezetimibe
  • Ezetimibe impurity RRS
  • (3R,4R,3&rsquo
  • RRS-Ezetimibe Q: What are the applications of
  • See more synonyms
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