CAS 163451-81-8

Teriflunomide

Description:

Teriflunomide is an immunomodulatory drug primarily used in the treatment of multiple sclerosis. It is a pyrimidine synthesis inhibitor that works by selectively inhibiting the enzyme dihydroorotate dehydrogenase, which is crucial for the proliferation of activated lymphocytes. This mechanism reduces the number of circulating lymphocytes, thereby modulating the immune response. Teriflunomide is characterized by its relatively long half-life, allowing for once-daily oral dosing. The compound is typically presented as a racemic mixture, with its active form being the levorotatory isomer. It has a moderate solubility in water and is lipophilic, which aids in its absorption and distribution in the body. Common side effects may include liver enzyme elevations, gastrointestinal disturbances, and potential teratogenic effects, necessitating careful monitoring during treatment. Due to its immunosuppressive properties, it is essential for patients to be screened for infections and other contraindications before initiating therapy. Overall, Teriflunomide represents a significant advancement in the management of autoimmune conditions, particularly multiple sclerosis.

Formula: C₁₂H₉F₃N₂O₂

InChI: InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7-

InChI key: InChIKey=UTNUDOFZCWSZMS-YFHOEESVSA-N

SMILES: C(F)(F)(F)C1=CC=C(NC(/C(=C(/C)\O)/C#N)=O)C=C1

Synonyms:

• (2Z)-2-(hydroxy{[4-(trifluoromethyl)phenyl]amino}methylidene)-3-oxobutanenitrile
• (2Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
• (Z)-2-Cyano-alpha'alpha'alpha-trifluoro-3-hydroxy-p-crotonotoluidide
• 2-Butenamide, 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-
• 2-Butenamide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-, (2Z)-
• 2-Butenamide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-, (Z)-
• 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-butenamide
• A 1726
• A 77-1726
• A 771726
• A771726
• Active metabolite of leflunomide
• Aubagio
• Femorix
• Flucyamide
• Hmr 1726
• Malononitrilamide
• N-(4-Trifluoromethylphenyl)-2-cyano-2-hydroxycrotonamide
• Su 20
• Teriflunomide
• Teriflunomide [INN]

Teriflunomide

CAS: 163451-81-8

Purity: 95%

Molecular weight: 270.06

Ref: 10-F554435

Teriflunomide (Standard)

CAS: 163451-81-8

Teriflunomide (Standard) is a reference standard for research and analysis in studies involving Teriflunomide. Teriflunomide (A 77-1726) is the principal active metabolite of leflunomide, an approved therapy for rheumatoid arthritis and multiple sclerosis.

Formula: C₁₂H₉F₃N₂O₂

Color and Shape: Solid

Molecular weight: 270.21

Ref: TM-TMSM-3623