CAS 163515-35-3

CHLOROTOXIN

Description:

Chlorotoxin is a peptide derived from the venom of the venomous green mamba snake (Dendroaspis angusticeps). It is characterized by its small size and specific structure, which allows it to selectively bind to certain ion channels, particularly the chloride channels in cells. This binding can disrupt normal cellular functions, making chlorotoxin a subject of interest in cancer research, particularly for its potential use in targeting glioma cells. The substance has been studied for its ability to selectively bind to tumor cells while sparing normal cells, which could lead to novel therapeutic approaches. Chlorotoxin is also known for its fluorescent properties when conjugated with other molecules, enabling it to serve as a marker in imaging studies. Its unique mechanism of action and specificity make it a valuable tool in both basic research and potential clinical applications. However, due to its origin from snake venom, safety and ethical considerations are paramount in its use and study.

Formula: C₁₅₈H₂₅₆N₅₂O₄₈S₁₁

Synonyms:

• Cltx
• Cltx (Egyptian Scorpion)
• H-Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys-Asp-Asp-Cys-Cys-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys-Tyr-Gly-Pro-Gln-Cys-Leu-Cys-Arg-Nh2
• H-Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys-Asp-Asp-Cys-Cys-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys-Tyr-Gly-Pro-Gln-Cys-Leu-Cys-Arg-Nh2, (Disulfide Bonds Between Cys2 And Cys19/Cys5 And Cys28/Cys16 And Cys33/Cys20 And Cys35)
• H-Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys-Asp-Asp-Cys-Cys-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys-Tyr-Gly-Pro-Gln-Cys-Leu-Cys-Arg-Oh
• Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys-Asp-Asp-Cys-Cys-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys-Tyr-Gly-Pro-Gln-Cys-Leu-Cys-Arg-Nh2
• Chlorotoxin, Recombinant, Expressed
• chlorotoxin from leiurus quinquestriatus (north africa)
• CHLOROTOXIN
• Tm 601
• Chlorotoxin, >97%
• Tm601 peptide
• Chlorotoxin
• Chlorotoxin trifluoroacetate salt

Chlorotoxin

CAS: 163515-35-3

As chlorotoxin has shown a remarkable affinity for binding to tumor cells, it has been conjugated to cancer drugs or radionuclides for diagnostic or therapeutic uses.

Formula: C₁₅₈H₂₄₉N₅₃O₄₇S₁₁

Purity: 98.8%

Molecular weight: 3995.77

Ref: 01-4079411

Chlorotoxin

CAS: 163515-35-3

As chlorotoxin targets cancer cells, it was conjugated to drugs as cisplatin or dyes.

Formula: C₁₅₈H₂₄₉N₅₃O₄₇S₁₁

Purity: ≥ 98%

Color and Shape: Whitish Powder

Molecular weight: 3995.77

Ref: 01-4044876

Chlorotoxin

CAS: 163515-35-3

Formula: C₁₅₈H₂₄₉N₅₃O₄₇S₁₁

Purity: 97%

Color and Shape: Solid

Molecular weight: 3995.7096

Ref: IN-DA00AOY8

Chlorotoxin

CAS: 163515-35-3

Chlorotoxin: 36-amino acid peptide from deathstalker scorpion venom; blocks small chloride channels.

Formula: C₁₅₈H₂₄₉N₅₃O₄₇S₁₁

Purity: 98%

Color and Shape: Solid

Molecular weight: 3995.71

Ref: TM-TP1431

Chlorotoxin

CAS: 163515-35-3

Formula: C₁₅₈H₂₅₆N₅₂O₄₈S₁₁

Molecular weight: 4004.76

Ref: 7W-GK3925

Chlorotoxin

CAS: 163515-35-3

Chlorotoxin is an ion channel activator that is characterized by its high purity and affinity. It has been shown to bind to the acetylcholine receptor in the brain, which leads to increased levels of acetylcholine at the synapse and subsequent activation of postsynaptic neurons. Chlorotoxin also inhibits potassium channels, leading to hyperpolarization of cells and a decrease in neuronal activity. The peptide is used as a research tool for cell biology and pharmacology studies.

Formula: C₁₅₈H₂₄₉N₅₃O₄₇S₁₁

Purity: Min. 95%

Molecular weight: 3,995.7 g/mol

Ref: 3D-PCN-4282-V

Chlorotoxin from Leiurus quinquestriatus (north Africa)

CAS: 163515-35-3

Chlorotoxin is a neurotoxic peptide that belongs to the class of macrocyclic lactones. It was originally isolated from the venom of the deathstalker scorpion, Leiurus quinquestriatus, which is found in North Africa. Chlorotoxin has potent immunosuppressive and cytotoxic effects that are mediated by its ability to bind to ion channels in cell membranes through disulfide bonds. This peptide induces apoptosis and inhibits tumor growth in mice by targeting cancer cells and inducing cell death. The chlorotoxin molecule is conjugated with a variety of molecules to increase its stability and bioavailability for delivery into cells.

Formula: C₁₅₈H₂₅₆N₅₂O₄₈S₁₁

Purity: Min. 95%

Molecular weight: 4,004.76 g/mol

Ref: 3D-NGA51535

Chlorotoxin trifluoroacetate salt

CAS: 163515-35-3

Chlorotoxin trifluoroacetate salt is a chlorotoxin derivative that has been modified to be more soluble in aqueous solutions. It is used to identify skin cancer and other forms of cancer, as well as for the study of cellular function and structure. The molecule can be injected into tissue or cells, where it binds to nuclei and causes cell death. Chlorotoxin trifluoroacetate salt has minimal toxicity in humans and can be used on histological specimens with little disruption to the tissue. This reagent may also be used to target intracellular targets such as glioma cells.

Formula: C₁₅₈H₂₄₉N₅₃O₄₇S₁₁

Purity: Min. 95%

Molecular weight: 3,995.72 g/mol

Ref: 3D-FC109715