CAS 163521-12-8

Vilazodone

Description:

Vilazodone is a pharmaceutical compound primarily used as an antidepressant, classified as a selective serotonin reuptake inhibitor (SSRI) and a partial agonist at the serotonin receptor 5-HT1A. Its chemical formula is C26H28N4O2S, and it features a complex structure that includes a benzodioxole moiety and a thiophene ring. Vilazodone is known for its dual mechanism of action, which not only increases serotonin levels in the brain by inhibiting its reuptake but also enhances serotonergic neurotransmission through its partial agonist activity. This unique profile may contribute to its efficacy in treating major depressive disorder while potentially offering a favorable side effect profile compared to traditional SSRIs. The substance is typically administered orally and is metabolized primarily in the liver, with a half-life that supports once-daily dosing. Common side effects may include gastrointestinal disturbances, insomnia, and sexual dysfunction, similar to other antidepressants. Overall, vilazodone represents a significant advancement in the pharmacological management of depression.

Formula: C₂₆H₂₇N₅O₂

InChI: InChI=1S/C26H27N5O2/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32)

InChI key: InChIKey=SGEGOXDYSFKCPT-UHFFFAOYSA-N

SMILES: C(CCCN1CCN(CC1)C=2C=C3C(=CC2)OC(C(N)=O)=C3)C=4C=5C(NC4)=CC=C(C#N)C5

Synonyms:

• 1-[4-(5-Cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine
• 2-Benzofurancarboxamide, 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-
• 5-(4-(4-(5-Cyanoindol-3-yl)butyl)-1-piperazinyl)-2-benzofurancarboxamide
• 5-[4-[4-(5-Cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-benzofurancarboxamide
• Emd 515259
• Unii-S239O2Oov3
• Vilazodone
• 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide
• 5-[4-[4-(5-Cyanoindol-3-yl)butyl]piperazin-1-yl]benzofuran-2-carboxamide
• Vilazodone HCL
• 5-(4-(4-(5-cyano-1H-indol-3-yl) butyl) piperazin-1-yl) benzofuran-2-carboxaMide hydrochloride
• 5-(4-(4-(5-Cyano-1H-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxamide
• Vilazodonei
• Vilazodone-d6

Vilazodone

CAS: 163521-12-8

Vilazodone (SB659746A): an SSRI and 5-HT-1A agonist, boosts serotonin to treat depression and anxiety.

Formula: C₂₆H₂₇N₅O₂

Purity: 99.61%

Color and Shape: Light Yellow Solid

Molecular weight: 441.52

Ref: TM-T1279

2-Benzofurancarboxamide, 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-

CAS: 163521-12-8

Formula: C₂₆H₂₇N₅O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 441.5249

Ref: IN-DA001U71

Vilazodone

CAS: 163521-12-8

Vilazodone

Purity: ≥98%

Molecular weight: 441.52g/mol

Ref: 54-BUP08754

Vilazodone hydrochloride

CAS: 163521-12-8

Formula: C₂₆H₂₇N₅O₂·HCl

Purity: ≥ 99.0%

Color and Shape: White powder

Molecular weight: 477.98

Ref: 7W-GX6918

Vilazodone

Controlled Product

CAS: 163521-12-8

Stability Very Hygroscopic
Applications It is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. Antidepressant.
References Bartoszyk, G., et al.: Eur. J. Pharmacol., 322, 147 (19970, Heinrich, T., et al.: J. Med. Chem., 47, 4684 (2004),

Formula: C₂₆H₂₇N₅O₂

Color and Shape: Neat

Molecular weight: 441.52

Ref: TR-V265000

Vilazodone

CAS: 163521-12-8

Purity: 98%

Molecular weight: 441.216

Ref: 10-F861988

Vilazodone Carboxylic Acid-d4

Controlled Product

CAS: 163521-12-8

Formula: C₂₆H₂₂D₄N₄O₃

Color and Shape: Neat

Molecular weight: 441.52

Ref: TR-V265012

N-(5-Cyano-1H-indol-3-yl)butyl Vilazodone Piperazinium Salt

Controlled Product

CAS: 163521-12-8

Formula: C₃₉H₄₀NN₆O₂•X

Color and Shape: Neat

Molecular weight: 638.78+(XX.XX)

Ref: TR-C980460