CAS 163837-48-7

(S)-Cetirizine Dihydrochloride

Description:

(S)-Cetirizine Dihydrochloride is an antihistamine used primarily for the treatment of allergic conditions such as hay fever, urticaria, and other allergic reactions. It is the dihydrochloride salt of cetirizine, which is a second-generation antihistamine derived from the piperazine class. This compound exhibits selective antagonism of peripheral H1 receptors, effectively reducing symptoms associated with histamine release, such as itching, sneezing, and runny nose. (S)-Cetirizine is characterized by its relatively low sedative properties compared to first-generation antihistamines, making it suitable for daytime use. The substance is typically administered orally and is well-absorbed in the gastrointestinal tract. Its pharmacokinetics indicate a long half-life, allowing for once-daily dosing. Additionally, (S)-Cetirizine is known for its favorable safety profile, with common side effects including drowsiness and dry mouth. The compound is soluble in water, which facilitates its formulation in various dosage forms, including tablets and syrups. Overall, (S)-Cetirizine Dihydrochloride is a widely used medication in managing allergic symptoms effectively.

Formula: C₂₁H₂₇Cl₃N₂O₃

Synonyms:

• Dextro Cetirizine HydrochlorideQ: What is
• Cetirizine Impurity 21
• Dextro Cetirizine Hydrochloride Q: What is the CAS Number of
• (S)-Cetirizine Dihydrochloride
• Dextro Cetirizine Hydrochloride
• (S)-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid dihydrochloride
• Cetirizine S-Isomer di HCl
• Dextro Cetirizine Hydrochloride Q: What is the storage condition of
• (S)-Cetirizine DiHCl
• Levocetrizine IMpurity: S-IsoMer IMpurity
• (S)-2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy) acetic acid, hydrochloride (1:2)
• Levocetirizine S-Isomer
• Cetirizine S-Isomer (HCl)
• Cetirizine Chiral Impurity

(S)-Cetirizine dihydrochloride

CAS: 163837-48-7

Formula: C₂₁H₂₇Cl₃N₂O₃

Color and Shape: Solid

Molecular weight: 461.8097

Ref: IN-DA001UF6

(S)-Cetirizine DiHCl

CAS: 163837-48-7

Formula: C₂₁H₂₅ClN₂O₃·2HCl

Color and Shape: Off-White Solid

Molecular weight: 388.89 2*36.46

Ref: 4Z-C-202

(S)-Cetirizine Dihydrochloride

CAS: 163837-48-7

Formula: C₂₁H₂₅ClN₂O₃HCl

Molecular weight: 388.89 : 72.92

Ref: ST-EA-CP-C14016

(S)-Cetirizine Dihydrochloride

CAS: 163837-48-7

Applications A nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic.
References De Vos, C., et al.: Ann. Allergy, 59, 278 (1987), Juhlin, L., et al.: J. Allergy Clin. Immunol., 80, 599 (1987), Fadel, R., et al.: Clin. Allergy, 17, 373 (1987), Gengo, F.M., et al.: Clin. Pharmacol. Ther., 42, 265 (1987)

Formula: C₂₁H₂₅ClN₂O₃·2ClH

Color and Shape: White

Molecular weight: 461.81

Ref: TR-C281105

(S)-Cetirizine dihydrochloride

CAS: 163837-48-7

Cetirizine is a levorotatory antihistamine that has been shown to have a linear response to changes in concentration. It is used as an anti-allergic agent for the treatment of allergic conjunctivitis and other allergic disorders. Cetirizine is an H1 receptor antagonist and its activity is due to competitive inhibition of histamine binding at this site. Cetirizine also inhibits the release of inflammatory mediators from mast cells, including histamine, prostaglandin D2, leukotrienes, and interleukins. This drug also has a rapid onset of action and it can be administered on a once-daily schedule.

Purity: Min. 95%

Molecular weight: 461.81

Ref: 3D-FC44789