CAS 163847-77-6

N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-L-alaninamide

Description:

N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-L-alaninamide is a complex organic compound characterized by its intricate structure, which includes multiple functional groups such as amides, amino acids, and a hydroxyamino moiety. This compound features a chiral center, indicating that it can exist in different stereoisomeric forms, which may influence its biological activity and interactions. The presence of a naphthalene ring suggests potential aromatic properties, contributing to its stability and reactivity. Additionally, the hydroxyamino group may play a role in hydrogen bonding and solubility in polar solvents. The compound's molecular structure implies potential applications in medicinal chemistry, particularly in the development of peptide-based therapeutics or as a biochemical probe. Its specific interactions and properties would depend on the surrounding environment, including pH and the presence of other biomolecules. Further studies would be necessary to elucidate its full range of characteristics and potential applications in various fields.

Formula: C₂₆H₃₇N₅O₅

InChI: InChI=1S/C26H37N5O5/c1-16(2)12-21(15-23(32)31-36)25(34)30-22(26(35)29-17(3)24(33)28-11-10-27)14-18-8-9-19-6-4-5-7-20(19)13-18/h4-9,13,16-17,21-22,36H,10-12,14-15,27H2,1-3H3,(H,28,33)(H,29,35)(H,30,34)(H,31,32)/t17-,21+,22-/m0/s1

InChI key: InChIKey=AWNBSWDIOCXWJW-WTOYTKOKSA-N

SMILES: C([C@H](NC([C@@H](CC(NO)=O)CC(C)C)=O)C(N[C@H](C(NCCN)=O)C)=O)C1=CC2=C(C=C1)C=CC=C2

Synonyms:

• L-Alaninamide, N-[(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-
• L-Alaninamide, N-[2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-, (R)-
• TNF-a protease inhibitor 1
• N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-L-alaninamide
• TAPI 1
• N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-L-Alaninamide acetate salt
• N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-NAPHTHYLALANYL-L-ALANINE, 2-AMINOETHYL AMIDE
• N-(R)-(2-(HYDROXYAMINOCARBONYL)METHYL)-4-METHYLPENTANOYL-L-3-(2'-NAPHTHYL)ALANYL-L-ALANINE 2-AMINOETHYL AMIDE
• N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)--alanyl-L-alaninamide
• HONHCOCH2CH(CH2-CH(CH3)2)CO-NAL-ALA-NHCH2CH2NH2
• TAPI-1 acetate salt
• (2R)-TAPI-1

TAPI-1

CAS: 163847-77-6

Formula: C₂₆H₃₇N₅O₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 499.6025

Ref: IN-DA00AB9J

TAPI-1

CAS: 163847-77-6

TAPI-1

Purity: ≥95%

Color and Shape: Solid

Molecular weight: 499.60g/mol

Ref: 54-BISN0029

TAPI-1

CAS: 163847-77-6

TAPI-1 is an inhibitor of TACE (TNF-α converting enzyme, also known as ADAM17) and matrix metalloproteinases (MMPs). It blocks the shedding of several cell surface proteins, including tumor necrosis factor-alpha (TNF-α), IL-6 receptor, and TNF receptors p60 (TNFRI) and p80 (TNFRII).

Formula: C₂₆H₃₇N₅O₅

Purity: Min. 95%

Molecular weight: 499.60 g/mol

Ref: 3D-INH-3855-PI

TAPI-1

CAS: 163847-77-6

Purity: 95%

Molecular weight: 499.6119995

Ref: 10-F863351

TAPI-1

CAS: 163847-77-6

TAPI1 (TAPI) , an ADAM17/TACE inhibitor, inhibits shedding of cytokine receptors.

Formula: C₂₆H₃₇N₅O₅

Purity: ≥95%

Color and Shape: Solid

Molecular weight: 499.6

Ref: TM-T6009