CAS 163878-63-5

Uridine,5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Description:

Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] is a complex nucleoside derivative characterized by its unique structural features that include a uridine base, multiple methoxyphenyl groups, and a phosphoramidite moiety. This compound is typically used in the field of nucleic acid chemistry, particularly in the synthesis of oligonucleotides, due to its ability to facilitate the incorporation of modified nucleotides into RNA or DNA strands. The presence of methoxy groups enhances solubility and stability, while the phosphoramidite functionality allows for efficient coupling reactions during oligonucleotide synthesis. Additionally, the cyanoethyl group contributes to the overall reactivity of the phosphoramidite, making it a valuable intermediate in the synthesis of various nucleic acid constructs. Overall, this compound exemplifies the intricate design often employed in the development of nucleoside analogs for research and therapeutic applications.

Formula: C₄₃H₅₅N₄O₁₀P

Synonyms:

• 5-Methyl-5'-DMT-2'-O-Methyl-Uridine
• DMT-2'-O-MOE-T-CE Phosphoramidite
• 5-Me-DMT-2'-O-MOE-U-CE-Phosphoramidite

(2R,3R,4R,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-4-(2-METHOXYETHOXY)-5-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE

CAS: 163878-63-5

Formula: C₄₃H₅₅N₄O₁₀P

Purity: 97%

Color and Shape: Solid

Molecular weight: 818.8914

Ref: IN-DA00ACOR

2'-O-Moe-5Meu-3'-Phosphoramidite

CAS: 163878-63-5

2'-O-Moe-5Meu-3'-Phosphoramidite

Purity: 97%

Molecular weight: 818.89g/mol

Ref: 54-OR1030050

5''-O-DMT-2''-O-methyl-5-methyluridine

CAS: 163878-63-5

Ref: 7W-GN7305

2'-O-MOE-5MeU-3'-phosphoramidite

CAS: 163878-63-5

2'-O-MOE-5MeU-3'-phosphoramidite is a Nucleoside Phosphoramidite.

Formula: C₄₃H₅₅N₄O₁₀P

Color and Shape: Solid

Molecular weight: 818.89

Ref: TM-TNU1113

DMT-2'-O-MOE-5-Me-rU Phosphoramidite

CAS: 163878-63-5

Formula: C₄₃H₅₅N₄O₁₀P

Purity: >95.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 818.90

Ref: 3B-D5985

5'-O-DMT-2'-O-(2-methoxyethyl)-5-methyluridine 3'-CE phosphoramidite

CAS: 163878-63-5

5'-O-DMT-2'-O-(2-methoxyethyl)-5-methyluridine 3'-CE phosphoramidite is a nucleoside phosphoramidite used as a building block for the introduction of uridine units into oligonucleotides. 5'-O-DMT-2'-O-(2-methoxyethyl)-5-methyluridine 3'-CE phosphoramidite is used for a broad range of applications including the synthesis of natural and unnatural DNA and RNA strands. Phosphoramidites are the reagent class of choice for oligonucleotide synthesis as they contain readily removable orthogonal protecting groups and can be produced at reasonable scales. The diisopropylamino leaving group is readily cleaved upon exposure to an azole catalyst allowing for a highly efficient coupling reaction with a free hydroxyl group on the growing oligonucleotide and oxidation of the subsequent phosphite triester, followed by beta-elimination of the cyanoethyl group affords the stable phosphodiester linkage.

Formula: C₄₃H₅₅N₄O₁₀P

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 818.89 g/mol

Ref: 3D-PD32565

2′-O-MOE-5MeU-3′-phosphoramidite

CAS: 163878-63-5

Purity: 97%

Molecular weight: 818.905

Ref: 10-F987264