CAS 1639137-80-6

Axitinib Impurity 27

Description:

Axitinib Impurity 27, with the CAS number 1639137-80-6, is a chemical compound that is recognized as an impurity associated with the pharmaceutical agent axitinib, which is primarily used in cancer treatment, particularly for renal cell carcinoma. While specific detailed characteristics of Axitinib Impurity 27 may not be widely documented, impurities in pharmaceutical compounds typically exhibit properties such as varying solubility in different solvents, potential biological activity, and distinct spectroscopic signatures. The presence of impurities can affect the efficacy and safety of the primary drug, making their characterization crucial in pharmaceutical development. Analytical techniques such as high-performance liquid chromatography (HPLC), mass spectrometry (MS), and nuclear magnetic resonance (NMR) spectroscopy are often employed to identify and quantify such impurities. Understanding the characteristics of impurities like Axitinib Impurity 27 is essential for ensuring the quality and regulatory compliance of pharmaceutical products.

Formula: C₂₄H₂₀N₄O₂S

Synonyms:

• Axitinib J
• N-Acetyl Axitinib
• Benzamide, 2-[[1-acetyl-3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-N-methyl-
• (E)-2-((1-acetyl-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)-N-methylbenzamide

Axitinib Impurity 27

CAS: 1639137-80-6

Formula: C₂₄H₂₀N₄O₂S

Molecular weight: 428.51

Ref: 4Z-A-188030

(E)-2-((1-Acetyl-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)-N-methylbenzamide (Axitinib Impurity)

CAS: 1639137-80-6

Purity: 97%

Color and Shape: Solid

Molecular weight: 428.51

Ref: 10-F988581

N-Acetyl Axitinib

Controlled Product

CAS: 1639137-80-6

Applications N-Acetyl Axitinib is an intermediate used in the synthesis of Axitinib. Axitinib is a tyrosine kinase inhibitor that is also used in cancer therapy.
References Chekal, B. P., et al.: Org. Process Res. Dev., 18, 266 (2014), Wasser, K., et al.: Eur. Radiol., 13, 80 (2003), Park, J., et al.: Clin. Cancer Res., 8, 1172 (2002), Bergers, G., et al.: J. Clin. Invest., 111, 1287 (2003),

Formula: C₂₄H₂₀N₄O₂S

Color and Shape: Neat

Molecular weight: 428.51

Ref: TR-A134560

N-Acetyl Axitinib

CAS: 1639137-80-6

Formula: C₂₄H₂₀N₄O₂S

Molecular weight: 428.51

Ref: ST-EA-CP-A34015