CAS 16392-60-2

3α,5α-Tetrahydronorethisterone

Description:

3α,5α-Tetrahydronorethisterone, with the CAS number 16392-60-2, is a synthetic progestin, which is a type of steroid hormone. It is derived from testosterone and is structurally related to other progestins used in hormonal therapies. This compound is characterized by its ability to bind to progesterone receptors, thereby mimicking the effects of natural progesterone in the body. It is typically used in various formulations for contraceptive purposes and in hormone replacement therapies. The chemical structure includes a steroid backbone with specific functional groups that contribute to its biological activity. As a progestin, it plays a crucial role in regulating menstrual cycles, supporting pregnancy, and influencing various metabolic processes. Its pharmacological properties include anti-estrogenic effects and the ability to modulate the endometrial lining, making it significant in reproductive health. Safety and efficacy profiles are essential considerations in its use, and it is subject to regulatory oversight in pharmaceutical applications.

Formula: C₂₀H₃₀O₂

InChI: InChI=1S/C20H30O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,13-18,21-22H,4-12H2,2H3/t13-,14+,15-,16+,17+,18-,19-,20-/m0/s1

InChI key: InChIKey=DPDZKJQFRFZZCW-GAXNORQESA-N

SMILES: C[C@@]12[C@]([C@]3([C@](CC1)([C@@]4([C@@](CC3)(C[C@H](O)CC4)[H])[H])[H])[H])(CC[C@]2(C#C)O)[H]

Synonyms:

• 17α-Ethynyl-5α-oestrane-3α,17β-diol
• 17α-Ethynyl-5α-estrane-3α,17β-diol
• 19-Nor-5α,17α-pregn-20-yne-3α,17-diol
• 19-Norpregn-20-yne-3,17-diol, (3α,5α,17α)-
• (3α,5α,17α)-19-Norpregn-20-yne-3,17-diol

Norethindrone Impurity 5

CAS: 16392-60-2

Formula: C₂₀H₃₀O₂

Molecular weight: 302.46

Ref: 4Z-N-2938

3α,5α-Tetrahydronorethisterone

Controlled Product

CAS: 16392-60-2

Applications A 3α-metabolite of progesterone receptor agonist Norethindrone (N676000) that acts as an estrogen receptor in osteoblastic cells. It also has novel nongenomic endothelium-independent vaso-relaxing effects.
References Lemus, A.E. et al.: J. Endocrinol., 200, 199 (2009); Perusquia, M. et al.: Eur. J. Pharmacol., 475, 161 (2003); Blom, M.J. et al.: Drug Metab. Disp., 29, 976 (2001);

Formula: C₂₀H₃₀O₂

Color and Shape: Neat

Molecular weight: 302.45

Ref: TR-T294135

3α,5α-Tetrahydronorethisterone

Controlled Product

CAS: 16392-60-2

3α,5α-Tetrahydronorethisterone is a compound that is derived from estradiol and is commonly used in hormonal contraceptives. It undergoes dehydration to form ethynodiol diacetate, which is the active progestin component. This compound can be quantified in urine and blood samples, making it a reliable marker for monitoring contraceptive use. 3α,5α-Tetrahydronorethisterone and its metabolites can also be isolated from urine and feces, providing valuable information about its metabolism and elimination from the body. This compound is widely used in controlled products for women's health and has been proven to be effective in preventing pregnancy when used as directed.

Formula: C₂₀H₃₀O₂

Purity: Min. 95%

Molecular weight: 302.5 g/mol

Ref: 3D-RAA39260

Norethindrone Impurity 5

CAS: 16392-60-2

Formula: C₂₀H₃₀O₂

Molecular weight: 302.46

Ref: ST-EA-CP-N52022