CAS 1642288-47-8

mavacamten

Description:

Mavacamten is a novel small molecule drug primarily developed for the treatment of hypertrophic cardiomyopathy (HCM), a condition characterized by abnormal thickening of the heart muscle. It functions as a selective inhibitor of cardiac myosin, which plays a crucial role in muscle contraction. By modulating the interaction between myosin and actin, mavacamten aims to reduce hypercontractility and improve cardiac function. The substance is typically administered orally and has undergone extensive clinical trials to evaluate its efficacy and safety profile. Mavacamten's mechanism of action allows for a targeted approach in managing HCM, potentially leading to improved symptoms and quality of life for patients. Its development reflects a growing trend in precision medicine, focusing on specific molecular targets to treat complex cardiovascular conditions. As with any pharmaceutical, monitoring for side effects and interactions with other medications is essential during treatment.

Formula: C₁₅H₁₉N₃O₂

Synonyms:

• MYK-461
• (S)-3-Isopropyl-6-((1-phenylethyl)amino)pyrimidine-2,4(1H,3H)-dione
• SAR 439152
• 3-(1-methylethyl)-6-[[(1S)-1-phenylethyl]amino]-2,4(1H,3H)-pyrimidinedione
• 6-[[(1S)-1-phenylethyl]amino]-3-propan-2-yl-1H-pyrimidine-2,4-dione
• Mavacamten (MYK-461
• SAR-439152; SAR 439152; SAR439152; MYK-461; MYK 461; MYK461; MAVACAMTEN
• 2,4(1H,3H)-Pyrimidinedione, 3-(1-methylethyl)-6-[[(1S)-1-phenylethyl]amino]-
• SAR439152
• MYK-461 - Mavacamten | SAR439152
• 6-([(1S)-1-phenylethyl]amino)-3-(propan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione

Mavacamten

CAS: 1642288-47-8

Formula: C₁₅H₁₉N₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 273.3303

Ref: IN-DA01EOND

Mavacamten

CAS: 1642288-47-8

Mavacamten

Purity: ≥98%

Molecular weight: 273.33g/mol

Ref: 54-BUP03126

(S)-3-Isopropyl-6-((1-Phenylethyl)Amino)Pyrimidine-2,4(1H,3H)-Dione

CAS: 1642288-47-8

(S)-3-Isopropyl-6-((1-Phenylethyl)Amino)Pyrimidine-2,4(1H,3H)-Dione

Purity: 99%

Molecular weight: 273.33g/mol

Ref: 54-OR1025421

Mavacamten

CAS: 1642288-47-8

Formula: C₁₅H₁₉N₃O₂

Molecular weight: 273.34

Ref: 4Z-M-294001

Mavacamten

CAS: 1642288-47-8

Mavacamten (MYK-461) is an orally bioavailable inhibitor of cardiac myosin ATPase,( IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively)

Formula: C₁₅H₁₉N₃O₂

Purity: 99.53% - 99.98%

Color and Shape: Solid

Molecular weight: 273.33

Ref: TM-T7134

Mavacamten

Controlled Product

CAS: 1642288-47-8

Formula: C₁₅H₁₉N₃O₂

Color and Shape: Neat

Ref: TR-M299810

Mavacamten

Controlled Product

CAS: 1642288-47-8

Mavacamten is a molecule that stabilizes myosin and has a cardioprotective effect. It inhibits the progression of cardiomyopathy by increasing the synthesis of cardiomyocyte proteins, including the AMP-activated protein kinase (AMPK). Mavacamten is also able to inhibit the filamentous actin in cardiac muscle cells, which may be related to its pharmacological treatment. Mavacamten can inhibit the caco-2 cell growth and induce apoptosis, but it does not have an inhibitory effect on cellular metabolism or on biochemical reactions. The symptoms of mavacamten are related to its ability to inhibit cardiac muscle contraction and relaxation.

Formula: C₁₅H₁₉N₃O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 273.33 g/mol

Ref: 3D-SQC28847