SAFit2, identified by the CAS number 1643125-33-0, is a chemical compound that has garnered attention in various fields, particularly in medicinal chemistry and biochemistry. While specific characteristics such as its molecular structure, physical properties, and reactivity may not be widely documented in public databases, compounds like SAFit2 are often designed for specific biological activities, potentially serving as inhibitors or modulators of certain biological pathways. Typically, such compounds may exhibit properties like solubility in organic solvents, stability under standard laboratory conditions, and specific interactions with biological targets. The development of SAFit2 likely involves considerations of its pharmacokinetics, toxicity, and efficacy in biological systems. For detailed information, including its synthesis, mechanism of action, and applications, consulting specialized scientific literature or databases would be essential, as these sources provide comprehensive insights into the compound's characteristics and potential uses in research or therapeutic contexts.

SAfit2 is a potent inhibitor of FK506-binding protein 51 (FKBP51; K
i
= 6 nM). It is highly selective for FKBP51 over FKBP52 (K
i
= >50,000 nM) and has increased brain permeability in comparison to SAfit1. SAfit2 (20 mg/kg) enhances HPA axis suppression in mice by decreasing plasma corticosterone levels to a greater extent than in control mice following dexamethasone administration. It also does not increase plasma corticosterone levels as high as in control mice following subsequent administration of corticotropin-releasing factor (CRF; ). It decreases the time spent immobile in the forced swim test and increases the time spent in the open arms of the elevated plus maze, indicating antidepressant-like and anxiolytic-like activity, respectfully.

SAFit2

1643125-33-0: SAFit2, identified by the CAS number 1643125-33-0, is a chemical compound that has garnered attention in various fields, particularly in medicinal chemistry and biochemistry. While specific characteristics such as its molecular structure, physical properties, and reactivity may not be widely documented in public databases, compounds like SAFit2 are often designed for specific biological activities, potentially serving as inhibitors or modulators of certain biological pathways. Typically, such compounds may exhibit properties like solubility in organic solvents, stability under standard laboratory conditions, and specific interactions with biological targets. The development of SAFit2 likely involves considerations of its pharmacokinetics, toxicity, and efficacy in biological systems. For detailed information, including its synthesis, mechanism of action, and applications, consulting specialized scientific literature or databases would be essential, as these sources provide comprehensive insights into the compound's characteristics and potential uses in research or therapeutic contexts.

<p>SAFit2 is a highly potent and selective inhibitor of fk506 binding protein 51 (FKBP51).Cost-effective and quality-assured</p>

CAS 1643125-33-0

SAFit2

SAFit2

Ref: 54-BUP12760

SAFit2

Ref: TM-T16836