CAS 1646198-77-7

tri-GalNAc-hexamine

CAS: 1646198-77-7

tri-GalNAc-hexamine

Purity: 98%

Molecular weight: 1528.75g/mol

Ref: 54-OR1073902

Tri-β-GalNAc-6-aminohexanoate

CAS: 1646198-77-7

Tri-b-GalNAc-6-aminohexanoate is a synthetic ligand designed to target the asialoglycoprotein receptor (ASGPR) on hepatocytes. The three terminal beta-N-acetylgalactosamine (GalNAc) sugars provide an efficient ASGPR binding. It serves as a platform for lysosomal targeting chimera (LYTAC) development, allowing for the creation of chimeras that specifically target unwanted proteins for degradation within hepatocytes. In addition, tri-b-GalNAc-6-aminohexanoate facilitates the delivery of therapeutic cargo, such as RNA or Cas9 complexes, directly to hepatocytes via ASGPR-mediated endocytosis. This approach is promising for gene therapy and RNAi applications in the liver due to the specificity of ASGPR targeting and the versatility of the conjugation moiety.

Formula: C₆₇H₁₂₁N₁₁O₂₈

Purity: Min. 95 Area-%

Molecular weight: 1,528.74 g/mol

Ref: 3D-MT184237