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CAS 16463-74-4

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Hydrocortisone 17-acetate

Description:
Hydrocortisone 17-acetate, with the CAS number 16463-74-4, is a synthetic corticosteroid that exhibits anti-inflammatory and immunosuppressive properties. It is derived from hydrocortisone, a naturally occurring steroid hormone produced by the adrenal glands. This compound is characterized by the presence of an acetate group at the 17-position, which enhances its lipophilicity and stability compared to its parent compound. Hydrocortisone 17-acetate is typically used in pharmaceutical formulations for topical applications, particularly in the treatment of various skin conditions such as eczema, dermatitis, and psoriasis. Its mechanism of action involves the modulation of gene expression, leading to reduced production of inflammatory mediators. The substance is generally well-tolerated, but potential side effects may include skin thinning and local irritation with prolonged use. As with other corticosteroids, it is important to use hydrocortisone 17-acetate under medical supervision to minimize risks and ensure effective treatment outcomes.
Formula:C23H32O6
InChI:InChI=1S/C23H32O6/c1-13(25)29-23(19(28)12-24)9-7-17-16-5-4-14-10-15(26)6-8-21(14,2)20(16)18(27)11-22(17,23)3/h10,16-18,20,24,27H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1
InChI key:InChIKey=HDEDWNHZBWFQCB-JZYPGELDSA-N
SMILES:C(CO)(=O)[C@]1(OC(C)=O)[C@]2(C)[C@@](CC1)([C@]3([C@]([C@@H](O)C2)([C@]4(C)C(CC3)=CC(=O)CC4)[H])[H])[H]
Synonyms:
  • (11Β)-11,21-Dihydroxy-3,20-Dioxopregn-4-En-17-Yl Acetate
  • (11β)-17-(Acetyloxy)-11,21-dihydroxypregn-4-ene-3,20-dione
  • 11,21-Dihydroxy-3,20-Dioxopregn-4-En-17-Yl Acetate
  • 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 17-acetate
  • Cortisol, 17-acetate
  • Hydrocortisone 17-acetate
  • Pregn-4-ene-3,20-dione, 17-(acetyloxy)-11,21-dihydroxy-, (11β)-
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