CAS 164656-23-9
:Dutasteride
Description:
Dutasteride is a synthetic 5-alpha-reductase inhibitor primarily used in the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness. It functions by inhibiting the conversion of testosterone to dihydrotestosterone (DHT), a hormone implicated in prostate growth and hair loss. Dutasteride is characterized by its high lipophilicity, allowing it to penetrate cell membranes effectively. The compound is typically administered orally and has a long half-life, which contributes to its sustained action in reducing DHT levels. It is known for its potential side effects, which may include sexual dysfunction, gynecomastia, and changes in liver enzyme levels. Additionally, due to its mechanism of action, it is contraindicated in women, particularly during pregnancy, as it can affect fetal development. The chemical structure of dutasteride includes a steroid-like backbone, which is essential for its biological activity. Overall, dutasteride represents a significant advancement in the management of conditions related to DHT.
Formula:C27H30F6N2O2
InChI:InChI=1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1
InChI key:InChIKey=JWJOTENAMICLJG-QWBYCMEYSA-N
SMILES:C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@@](CC3)(NC(=O)C=C4)[H])(CC1)[H])[H])(CC[C@@H]2C(NC5=C(C(F)(F)F)C=CC(C(F)(F)F)=C5)=O)[H]
Synonyms:- (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide
- (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
- (4aR,6aS,7S)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
- (4aR,6aS,7S,9aS,9bS,11aR)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
- (5Alpha,17Beta)-N-{2,5-Bis(Trifluoromethyl)Phenyl}-3-Oxo-4-Azaandrost-L-Ene-17-Carboxamide
- (5α,17β)-N-[(2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-aza-5-androst-1-ene-17-carboxamide
- 1H-Indeno[5,4-f]quinoline-7-carboxamide, N-[2,5-bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, (4aR,4bS,6aS,7S,9aS,9bS,11aR)-
- 4-Azaandrost-1-ene-17-carboxamide, N-[2,5-bis(trifluoromethyl)phenyl]-3-oxo-, (5α,17β)-
- Avodart
- Avolve
- Gg 745
- Gi 198745
- Veltride
- See more synonyms
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Found 18 products.
DUTASTERIDE FOR SYSTEM SUITABILITY CRS
CAS:DUTASTERIDE FOR SYSTEM SUITABILITY CRSFormula:C27H30F6N2O2Color and Shape:White To Slightly Yellow. Powder., White To Slightly Yellow. Powder.Molecular weight:528.5297DUTASTERIDE CRS
CAS:DUTASTERIDE CRSFormula:C27H30F6N2O2Color and Shape:AddedMolecular weight:528.5297Dutasteride
CAS:Adrenal cortical hormones and their derivatives nesoiFormula:C27H30F6N2O2Color and Shape:White Pale Yellow PowderMolecular weight:528.221151H-Indeno[5,4-f]quinoline-7-carboxamide, N-[2,5-bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, (4aR,4bS,6aS,7S,9aS,9bS,11aR)-
CAS:Formula:C27H30F6N2O2Purity:98%Color and Shape:SolidMolecular weight:528.5297Dutasteride
CAS:Dutasteride (GI 198745) is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostaticFormula:C27H30F6N2O2Purity:99.58%Color and Shape:White Crystalline SolidMolecular weight:528.53Ref: TM-T1499
5mg35.00€10mg54.00€25mg84.00€50mg100.00€100mg150.00€200mg203.00€500mg341.00€1mL*10mM (DMSO)54.00€Dutasteride
CAS:Formula:C27H30F6N2O2Purity:≥ 98.0%Color and Shape:White to almost white crystalline powderMolecular weight:528.53Dutasteride-13C6
CAS:Formula:C2113C6H30F6N2O2Color and Shape:White To Off-White SolidMolecular weight:534.49Dutasteride
CAS:Formula:C27H30F6N2O2Purity:>98.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:528.54Dutasteride Impurity 5
CAS:Formula:C27H31F6NO3Color and Shape:White To Off-White SolidMolecular weight:531.54Dutasteride
CAS:Controlled ProductApplications Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia.
References Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995), Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999), Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005),Formula:C27H30F6N2O2Color and Shape:NeatMolecular weight:528.53Dutasteride - Bio-X ™
CAS:Dutasteride is an androgenic compound and a 5α-reductase inhibitor that is used to treat benign prostatic hyperplasia (BPH) and male pattern baldness. Dutasteride reduces prostate volume and improves symptoms of BPH by inhibiting the enzyme 5α-reductase, which converts testosterone to dihydrotestosterone.Formula:C27H30F6N2O2Purity:(%) Min. 99%Color and Shape:PowderMolecular weight:528.53 g/molDutasteride
CAS:A dual irreversible inhibitor of 5α-reductase isoforms 5AR1 and 5AR2 with IC50 of 6 nM and 7 nM, respectively. It supresses the production of dihydrotestosterone and has been used for the treatment of benign prostatic hyperplasia, alopecia and hirsutism in women with polycystic ovary syndrome. In rodent models for Parkinson’s disease, Dutasteride reduced L-DOPA-induced dyskinesia without altering the therapeutic effect of L-DOPA.
Formula:C27H30F6N2O2Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:528.53 g/mol
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