CAS 164656-23-9: Dutasteride

Description: Dutasteride is a synthetic 5-alpha-reductase inhibitor primarily used in the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness. It functions by inhibiting the conversion of testosterone to dihydrotestosterone (DHT), a hormone implicated in prostate growth and hair loss. Dutasteride is characterized by its high lipophilicity, allowing it to penetrate cell membranes effectively. The compound is typically administered orally and has a long half-life, which contributes to its sustained action in reducing DHT levels. It is known for its potential side effects, which may include sexual dysfunction, gynecomastia, and changes in liver enzyme levels. Additionally, due to its mechanism of action, it is contraindicated in women, particularly during pregnancy, as it can affect fetal development. The chemical structure of dutasteride includes a steroid-like backbone, which is essential for its biological activity. Overall, dutasteride represents a significant advancement in the management of conditions related to DHT.

Formula: C₂₇H₃₀F₆N₂O₂

InChI: InChI=1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1

InChI key: InChIKey=JWJOTENAMICLJG-QWBYCMEYSA-N

SMILES: O=C1C=CC2(C)C(N1)CCC3C2CCC4(C)C(C(=O)NC5=CC(=CC=C5C(F)(F)F)C(F)(F)F)CCC34

Synonyms:

• (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide
• (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
• (4aR,6aS,7S)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
• (4aR,6aS,7S,9aS,9bS,11aR)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
• (5Alpha,17Beta)-N-{2,5-Bis(Trifluoromethyl)Phenyl}-3-Oxo-4-Azaandrost-L-Ene-17-Carboxamide
• (5α,17β)-N-[(2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-aza-5-androst-1-ene-17-carboxamide
• 1H-Indeno[5,4-f]quinoline-7-carboxamide, N-[2,5-bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, (4aR,4bS,6aS,7S,9aS,9bS,11aR)-
• 4-Azaandrost-1-ene-17-carboxamide, N-[2,5-bis(trifluoromethyl)phenyl]-3-oxo-, (5α,17β)-
• Avodart
• Avolve
• Gg 745
• Gi 198745
• Veltride
• Dutasteride

Dutasteride CRS

CAS: 164656-23-9

• Formula: C₂₇H₃₀F₆N₂O₂
• Color and Shape: White To Slightly Yellow. Powder., White To Slightly Yellow. Powder.
• Molecular weight: 528.5297

Dutasteride for system suitability CRS

CAS: 164656-23-9

• Formula: C₂₇H₃₀F₆N₂O₂
• Color and Shape: White To Slightly Yellow. Powder., White To Slightly Yellow. Powder.
• Molecular weight: 528.5297

Dutasteride

CAS: 164656-23-9

Adrenal cortical hormones and their derivatives nesoi

• Formula: C₂₇H₃₀F₆N₂O₂
• Color and Shape: White Pale Yellow Powder
• Molecular weight: 528.22115

1H-Indeno[5,4-f]quinoline-7-carboxamide, N-[2,5-bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, (4aR,4bS,6aS,7S,9aS,9bS,11aR)-

CAS: 164656-23-9

• Formula: C₂₇H₃₀F₆N₂O₂
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 528.5297191999998

Dutasteride

CAS: 164656-23-9

Dutasteride (GI 198745) is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of …

• Formula: C₂₇H₃₀F₆N₂O₂
• Purity: 99.58%
• Color and Shape: White Crystalline Solid
• Molecular weight: 528.53

Dutasteride

CAS: 164656-23-9

• Formula: C₂₇H₃₀F₆N₂O₂
• Color and Shape: White To Off-White Solid
• Molecular weight: 528.54

Dutasteride

CAS: 164656-23-9

• Molecular weight: 528.534g/mol

Dutasteride

CAS: 164656-23-9

• Purity: 99.68%
• Molecular weight: 528.53g/mol

Dutasteride

CAS: 164656-23-9

• Formula: C₂₇H₃₀F₆N₂O₂
• Purity: ≥ 98.0%
• Color and Shape: White to almost white crystalline powder
• Molecular weight: 528.53

Dutasteride-13C6

CAS: 164656-23-9

• Formula: C₂₁₁₃C₆H₃₀F₆N₂O₂
• Color and Shape: White To Off-White Solid
• Molecular weight: 534.49

Dutasteride

CAS: 164656-23-9

• Formula: C₂₇H₃₀F₆N₂O₂
• Color and Shape: Neat
• Molecular weight: 528.53

Dutasteride

CAS: 164656-23-9

• Formula: C₂₇H₃₀F₆N₂O₂
• Purity: >98.0%(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 528.54

Dutasteride Impurity 5

CAS: 164656-23-9

• Formula: C₂₇H₃₁F₆NO₃
• Color and Shape: White To Off-White Solid
• Molecular weight: 531.54

Dutasteride

CAS: 164656-23-9

• Purity: 95.0%
• Color and Shape: Solid
• Molecular weight: 528.5390014648438

Dutasteride

CAS: 164656-23-9

Applications Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related …

• Formula: C₂₇H₃₀F₆N₂O₂
• Color and Shape: Neat
• Molecular weight: 528.53

Dutasteride - Bio-X ™

CAS: 164656-23-9

Dutasteride is an androgenic compound and a 5α-reductase inhibitor that is used to treat benign …

• Formula: C₂₇H₃₀F₆N₂O₂
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 528.53 g/mol

Dutasteride

CAS: 164656-23-9

A dual irreversible inhibitor of 5α-reductase isoforms 5AR1 and 5AR2 with IC50 of 6 nM …

• Formula: C₂₇H₃₀F₆N₂O₂
• Purity: Min. 98 Area-%
• Color and Shape: White Powder
• Molecular weight: 528.53 g/mol