CAS 164658-13-3

3-[(4-{2-[(3-chlorophenyl)amino]pyrimidin-4-yl}pyridin-2-yl)amino]propan-1-ol

Description:

The chemical substance known as 3-[(4-{2-[(3-chlorophenyl)amino]pyrimidin-4-yl}pyridin-2-yl)amino]propan-1-ol, with the CAS number 164658-13-3, is a complex organic compound characterized by its multi-ring structure and the presence of various functional groups. It features a propanol backbone, which contributes to its potential solubility in polar solvents. The compound contains a pyrimidine and a pyridine ring, both of which are nitrogen-containing heterocycles, enhancing its biological activity and potential as a pharmaceutical agent. The presence of a chlorophenyl group suggests possible interactions with biological targets, making it of interest in medicinal chemistry. Additionally, the amino groups in the structure may facilitate hydrogen bonding, influencing its reactivity and interaction with other molecules. Overall, this compound's intricate structure and functional groups suggest it may exhibit significant pharmacological properties, warranting further investigation in drug development and therapeutic applications.

Formula: C₁₈H₁₈ClN₅O

InChI: InChI=1/C18H18ClN5O/c19-14-3-1-4-15(12-14)23-18-22-9-6-16(24-18)13-5-8-21-17(11-13)20-7-2-10-25/h1,3-6,8-9,11-12,25H,2,7,10H2,(H,20,21)(H,22,23,24)

SMILES: c1cc(cc(c1)Nc1nccc(c2cc[nH]c(=NCCCO)c2)n1)Cl

Synonyms:

• 3-(4-(2-(3-Chlorophenylamino)Pyrimidin-4-Yl)Pyridin-2-Ylamino)Propanol

1-Propanol, 3-[[4-[2-[(3-chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-

CAS: 164658-13-3

Formula: C₁₈H₁₈ClN₅O

Purity: 99%

Color and Shape: Solid

Molecular weight: 355.8214

Ref: IN-DA001V0A

CGP60474

CAS: 164658-13-3

CGP60474

Purity: ≥98%

Molecular weight: 355.82g/mol

Ref: 54-BUP04157

3-((4-(2-((3-Chlorophenyl)Amino)Pyrimidin-4-Yl)Pyridin-2-Yl)Amino)Propan-1-Ol

CAS: 164658-13-3

3-((4-(2-((3-Chlorophenyl)Amino)Pyrimidin-4-Yl)Pyridin-2-Yl)Amino)Propan-1-Ol

Purity: 98%

Molecular weight: 355.82g/mol

Ref: 54-OR1023338

CGP60474

CAS: 164658-13-3

Purity: 99%

Molecular weight: 355.12

Ref: 10-F861996

CGP 60474

Controlled Product

CAS: 164658-13-3

Applications CGP 60474 is type of protein kinase C inhibitor (ckd1/cdk2) used in the treatment of different cancers
References Stanetty, P. et al.: J. Org. Chem., 70, 5215 (2005);

Formula: C₁₈H₁₈ClN₅O

Color and Shape: Neat

Molecular weight: 355.821

Ref: TR-C291780

CGP60474

CAS: 164658-13-3

CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC.

Formula: C₁₈H₁₈ClN₅O

Purity: 98.81%

Color and Shape: Solid

Molecular weight: 355.82

Ref: TM-T14943

CGP 60474

CAS: 164658-13-3

CGP 60474 is a neurotrophic factor that has been shown to be beneficial for the treatment of inflammatory bowel disease. It binds to intracellular targets, such as kinases, and prevents them from being activated by other molecules. CGP 60474 has also been used in diagnosis of autoimmune diseases and HIV infection. CGP 60474 is a combination preparation with an inhibitor of viral replication that is active against HIV-1, HIV-2, and SIV. The drug inhibits viral replication by binding to the viral envelope protein gp120 and preventing it from binding to the host CD4 receptor on T cells. This prevents viral entry into the cell and subsequent integration into the host genome.

Formula: C₁₈H₁₈ClN₅O

Purity: Min. 95%

Molecular weight: 355.82 g/mol

Ref: 3D-PGA65813