CAS 164802-68-0

Siamycin I (9CI)

Description:

Siamycin I (9CI) is a natural product derived from the fermentation of specific strains of Streptomyces bacteria. It is classified as a macrolide antibiotic, characterized by its large lactone ring structure, which is typical of this class of compounds. Siamycin I exhibits potent antibacterial activity, particularly against a range of Gram-positive bacteria, making it of interest in medicinal chemistry and pharmacology. Its mechanism of action primarily involves the inhibition of protein synthesis, disrupting bacterial growth and replication. Additionally, Siamycin I has shown potential in antitumor activity, indicating its versatility beyond antibacterial applications. The compound's solubility and stability can vary depending on the formulation and environmental conditions, which are critical factors for its therapeutic use. As with many antibiotics, the development of resistance is a concern, necessitating ongoing research into its efficacy and potential combinations with other antimicrobial agents. Overall, Siamycin I represents a significant compound in the study of natural antibiotics and their applications in treating bacterial infections.

Formula: C₉₇H₁₃₁N₂₃O₂₆S₄

Synonyms:

• 2: PN:WO2007106472 FIGURE: 4 claimed protein
• Bmy 29304
• Fr 901724
• L-Tryptophan,L-cysteinyl-L-leucylglycyl-L-valylglycyl-L-seryl-L-cysteinyl-L-asparaginyl-L-a-aspartyl-L-phenylalanyl-L-alanylglycyl-L-cysteinylglycyl-L-tyrosyl-L-alanyl-L-isoleucyl-L-valyl-L-cysteinyl-L-phenylalanyl-,cyclic (9® 1)-peptide, cyclic (1® 13),(7® 19)-bis(disulfide)
• Ms 271
• Np 06
• NP 06 (peptide)

Siamycin I

CAS: 164802-68-0

Siamycin I, a tricyclic peptide from Streptomyces, has anti-HIV (ED50: 0.05-5.7 μM) and antibacterial effects, also inhibits E. faecalis quorum sensing.

Formula: C₉₇H₁₃₁N₂₃O₂₆S₄

Molecular weight: 2163.49

Ref: TM-T37468

Siamycin I

CAS: 164802-68-0

Formula: C₉₇H₁₃₁N₂₃O₂₆S₄

Purity: ≥ 85.0%

Color and Shape: White solid

Molecular weight: 2163.5

Ref: 7W-GL1634