CAS 16503-32-5

Brevilin A

Description:

Brevilin A is a natural compound classified as a sesquiterpene lactone, primarily derived from the plant species *Centipeda minima*. It is known for its potential pharmacological properties, including anti-inflammatory, antimicrobial, and anticancer activities. The molecular structure of Brevilin A features a unique bicyclic framework, which contributes to its biological activity. This compound has garnered interest in medicinal chemistry due to its ability to modulate various biological pathways, making it a candidate for further research in drug development. Additionally, Brevilin A exhibits a relatively low toxicity profile, which is advantageous for therapeutic applications. Its solubility characteristics can vary, influencing its bioavailability and efficacy in biological systems. Overall, Brevilin A represents a significant area of study within natural product chemistry, with ongoing investigations aimed at elucidating its mechanisms of action and potential therapeutic uses.

Formula: C₂₀H₂₆O₅

InChI: InChI=1S/C20H26O5/c1-6-10(2)18(22)25-17-16-12(4)19(23)24-14(16)9-11(3)13-7-8-15(21)20(13,17)5/h6-8,11-14,16-17H,9H2,1-5H3/b10-6-/t11-,12+,13+,14-,16-,17+,20+/m1/s1

InChI key: InChIKey=KUPPZVXLWANEJJ-UXPPPGSFSA-N

SMILES: O(C(/C(=C\C)/C)=O)[C@H]1[C@]2([C@@](C[C@@H](C)[C@]3([C@@]1(C)C(=O)C=C3)[H])(OC(=O)[C@H]2C)[H])[H]

Synonyms:

• 2-Butenoic acid, 2-methyl-, (3S,3aR,4S,4aR,7aR,8R,9aR)-2,3,3a,4,4a,5,7a,8,9,9a-decahydro-3,4a,8-trimethyl-2,5-dioxoazuleno[6,5-b]furan-4-yl ester, (2Z)-
• 2-Butenoic acid, 2-methyl-, 2,3,3a,4,4a,5,7a,8,9,9a-decahydro-3,4a,8-trimethyl-2,5-dioxoazuleno[6,5-b]furan-4-yl ester, [3S-[3α,3aβ,4β(Z),4aα,7aβ,8β,9aβ]]-
• 2-Butenoicacid, 2-methyl-,2,3,3a,4,4a,5,7a,8,9,9a-decahydro-3,4a,8-trimethyl-2,5-dioxoazuleno[6,5-b]furan-4-ylester, [3S-[3a,3ab,4b(Z),4aa,7ab,8b,9ab]]-
• 6-O-Angeloylplenolin
• 6-O-Angeloylprenolin
• Ambros-2-en-12-oic acid, 6a,8b-dihydroxy-4-oxo-, 12,8-lactone, 2-methylcrotonate, (Z)- (8CI)
• Ambros-2-en-12-oic acid, 6α,8β-dihydroxy-4-oxo-, 12,8-lactone, 2-methylcrotonate, (Z)-
• Azuleno[6,5-b]furan, 2-butenoic acid deriv.
• Brevelin A
• Brevilin A

2-Butenoic acid, 2-methyl-, (3S,3aR,4S,4aR,7aR,8R,9aR)-2,3,3a,4,4a,5,7a,8,9,9a-decahydro-3,4a,8-trimethyl-2,5-dioxoazuleno[6,5-b]furan-4-yl ester, (2Z)-

CAS: 16503-32-5

Formula: C₂₀H₂₆O₅

Purity: 99%

Color and Shape: Solid

Molecular weight: 346.4174

Ref: IN-DA001V82

Brevilin A

CAS: 16503-32-5

Brevilin A

Purity: ≥98%

Molecular weight: 346.42g/mol

Ref: 54-BUP08606

Brevilin A

CAS: 16503-32-5

Formula: C₂₀H₂₆O₅

Molecular weight: 346.42

Ref: 7W-GY9787

Brevilin A

CAS: 16503-32-5

Brevilin A

Purity: 99%

Molecular weight: 346.42g/mol

Ref: 54-BISN0015

Brevilin A

CAS: 16503-32-5

​Brevilin A is a strong impetus for the development of selective JAK-STAT inhibitors and therapeutic drugs in order to improve survival of patients with hyperactivated JAKs and STATs. Brevilin A shows antigiardial activity (IC50 = 16.1 μM) and is similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM).

Formula: C₂₀H₂₆O₅

Purity: 95%~99%

Molecular weight: 346.423

Ref: BP-SBP00989

Brevilin A

CAS: 16503-32-5

Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.

Formula: C₂₀H₂₆O₅

Purity: 99.97% - >99.99%

Color and Shape: Solid

Molecular weight: 346.42

Ref: TM-T4672

Brevilin a

CAS: 16503-32-5

Lactone

Formula: C₂₀H₂₆O₅

Purity: ≥ 90.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 346.42

Ref: 5G-84204