Description:2,4,5-Trifluorobenzaldehyde is an aromatic aldehyde characterized by the presence of three fluorine atoms attached to a benzene ring, specifically at the 2, 4, and 5 positions relative to the aldehyde functional group. This compound is notable for its high reactivity due to the electron-withdrawing nature of the fluorine atoms, which can influence its chemical behavior and interactions. It typically appears as a colorless to pale yellow liquid with a distinct odor. The presence of the aldehyde group contributes to its reactivity, making it a useful intermediate in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. Additionally, 2,4,5-trifluorobenzaldehyde may exhibit unique physical properties, such as a relatively low boiling point and moderate solubility in organic solvents. Its fluorinated structure can also impart specific characteristics, such as increased lipophilicity and altered metabolic stability, which are valuable in medicinal chemistry. Safety precautions should be observed when handling this compound due to its potential toxicity and reactivity.
Applications 2,4,5-Trifluorobenzaldehyde is a reactant in the enantioselective synthesis of (R)-selegiline, an anti-Parkinson's drug, (S)-benzphetamine, …
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