CAS 1650550-25-6: Enasidenib (mesylate)

Description: Enasidenib (mesylate) is a small molecule inhibitor primarily used in the treatment of acute myeloid leukemia (AML) with specific genetic mutations. It functions as a selective inhibitor of the isocitrate dehydrogenase 2 (IDH2) enzyme, which plays a crucial role in cellular metabolism and differentiation. By inhibiting IDH2, Enasidenib alters the metabolic pathways within cancer cells, leading to the accumulation of oncometabolites and promoting differentiation of leukemic cells. The mesylate salt form enhances its solubility and stability, facilitating its administration. Enasidenib is typically administered orally and has a favorable pharmacokinetic profile, allowing for once-daily dosing. Common side effects may include nausea, fatigue, and potential differentiation syndrome, which requires monitoring. Its development represents a significant advancement in targeted cancer therapies, particularly for patients with IDH2 mutations, providing a more personalized approach to treatment. As with any medication, its use should be guided by a healthcare professional, considering the specific clinical context and patient characteristics.

Synonyms:

• 2-methyl-1-((4-(6-(trifluoromethyl)pyridin-2-yl)-6-((2-(trifluoromethyl)pyridin-4-yl)amino)-1,3,5-triazin-2-yl)amino)propan-2-ol methanesulfonate
• AG-221 mesylate
• AG-221 salt

Enasidenibmesylate

CAS: 1650550-25-6

• Formula: C₂₀H₂₁F₆N₇O₄S
• Purity: 98%
• Molecular weight: 569.4807

Enasidenib mesylate

CAS: 1650550-25-6

• Purity: 99.86%
• Molecular weight: 569.48g/mol

Enasidenib mesylate

CAS: 1650550-25-6

Enasidenib mesylate (AG-221 mesylate) is a IDH2 inhibitor that promotes differentiation of leukemia myeloid cells …

• Formula: C₂₀H₂₁F₆N₇O₄S
• Purity: 99.86%
• Color and Shape: Solid
• Molecular weight: 569.48

Enasidenib Mesylate

CAS: 1650550-25-6

• Formula: C₁₉H₁₇F₆N₇O·CH₄O₃S
• Molecular weight: 599.55

Enasidenib mesylate

CAS: 1650550-25-6

Inhibitor of isocitrate dehydrogenase IDH2

• Formula: C₁₉H₁₇F₆N₇O•CH₄O₃S
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 569.48 g/mol