CAS 1650550-25-6

Enasidenib (mesylate)

Description:

Enasidenib (mesylate) is a small molecule inhibitor primarily used in the treatment of acute myeloid leukemia (AML) with specific genetic mutations. It functions as a selective inhibitor of the isocitrate dehydrogenase 2 (IDH2) enzyme, which plays a crucial role in cellular metabolism and differentiation. By inhibiting IDH2, Enasidenib alters the metabolic pathways within cancer cells, leading to the accumulation of oncometabolites and promoting differentiation of leukemic cells. The mesylate salt form enhances its solubility and stability, facilitating its administration. Enasidenib is typically administered orally and has a favorable pharmacokinetic profile, allowing for once-daily dosing. Common side effects may include nausea, fatigue, and potential differentiation syndrome, which requires monitoring. Its development represents a significant advancement in targeted cancer therapies, particularly for patients with IDH2 mutations, providing a more personalized approach to treatment. As with any medication, its use should be guided by a healthcare professional, considering the specific clinical context and patient characteristics.

Formula: C20H21F6N7O4S

InChI: InChI=1S/C19H17F6N7O.CH4O3S/c1-17(2,33)9-27-15-30-14(11-4-3-5-12(29-11)18(20,21)22)31-16(32-15)28-10-6-7-26-13(8-10)19(23,24)25;1-5(2,3)4/h3-8,33H,9H2,1-2H3,(H2,26,27,28,30,31,32);1H3,(H,2,3,4)

InChI key: ORZHZQZYWXEDDL-UHFFFAOYSA-N

SMILES: CC(C)(CNC1=NC(=NC(=N1)C2=NC(=CC=C2)C(F)(F)F)NC3=CC(=NC=C3)C(F)(F)F)O.CS(=O)(=O)O

Synonyms:

• 2-methyl-1-((4-(6-(trifluoromethyl)pyridin-2-yl)-6-((2-(trifluoromethyl)pyridin-4-yl)amino)-1,3,5-triazin-2-yl)amino)propan-2-ol methanesulfonate
• AG-221 mesylate
• AG-221 salt

Enasidenib mesylate

CAS: 1650550-25-6

Enasidenib mesylate

Formula: C₂₀H₂₁F₆N₇O₄S

Purity: ≥98%

Molecular weight: 569.48

Ref: 54-BUP10458

Enasidenib Mesylate

CAS: 1650550-25-6

Formula: C₁₉H₁₇F₆N₇O·CH₄O₃S

Molecular weight: 599.55

Ref: 4Z-K-031042

Enasidenib mesylate

CAS: 1650550-25-6

2-Methyl-1-((4-(6-(trifluoromethyl)pyridin-2-yl)-6-((2-(trifluoromethyl)pyridin-4-yl)amino)-1,3,5-triazin-2-yl)amino)propan-2-ol methanesulfonate

Formula: C₂₀H₂₁F₆N₇O₄S

Purity: 98%

Molecular weight: 569.48

Ref: IN-DG632604

Enasidenib mesylate

CAS: 1650550-25-6

Enasidenib mesylate (AG-221 mesylate) is a IDH2 inhibitor that promotes differentiation of leukemia myeloid cells for the treatment of acute myeloid leukemia.

Formula: C₂₀H₂₁F₆N₇O₄S

Purity: 99.85%

Color and Shape: Solid

Molecular weight: 569.48

Ref: TM-T2346L

Enasidenib mesylate

CAS: 1650550-25-6

Formula: C₂₀H₂₁F₆N₇O₄S

Molecular weight: 569.5

Ref: BE-RMCK020042