CAS 16541-19-8

6-thioguanosine 5'-diphosphate

Description:

6-Thioguanosine 5'-diphosphate (6-thio-GDP) is a nucleotide analog that plays a significant role in biochemical processes, particularly in the context of nucleic acid metabolism and signaling pathways. It is characterized by the presence of a thiol group at the 6-position of the guanine base, which distinguishes it from its natural counterpart, guanosine diphosphate (GDP). This modification can influence its interaction with enzymes and receptors, potentially altering cellular signaling and metabolic pathways. 6-thio-GDP is often used in research to study the mechanisms of nucleotide metabolism and the effects of thiol modifications on nucleotides. Its structural features include a ribose sugar, a diphosphate group, and the modified guanine base, which collectively contribute to its biological activity. The compound is soluble in water and can participate in various biochemical reactions, making it a valuable tool in molecular biology and pharmacology. Its CAS number, 16541-19-8, is a unique identifier that facilitates its recognition in chemical databases and literature.

Formula: C₁₀H₁₅N₅O₁₀P₂S

InChI: InChI=1/C10H15N5O10P2S/c11-10-13-7-4(8(28)14-10)12-2-15(7)9-6(17)5(16)3(24-9)1-23-27(21,22)25-26(18,19)20/h2-3,5-6,9,16-17H,1H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,28)/t3-,5-,6-,9?/m1/s1

SMILES: C([C@@H]1[C@H]([C@H](C(n2cnc3c2[nH]c(=N)nc3S)O1)O)O)OP(=O)(O)OP(=O)(O)O

Synonyms:

• 9beta-Ribofuranosyl-2-amino-6-mercaptopurine 5'-diphosphate
• Guanosine 5'-(beta-thio)diphosphate
• Thiogdp
• p(S)pg
• Guanosine 5'-(trihydrogen diphosphate), 6-thio-
• 2-amino-9-{5-O-[hydroxy(phosphonooxy)phosphoryl]-D-ribofuranosyl}-3,9-dihydro-6H-purine-6-thione
• 6-Thioguanosine 5'-diphosphate

Guanosine 5'-(trihydrogen diphosphate), 6-thio-

CAS: 16541-19-8

Formula: C₁₀H₁₅N₅O₁₀P₂S

Molecular weight: 459.2661

Ref: IN-DA001W55

Thioguanosine Diphosphate-13C,15N2

Controlled Product

CAS: 16541-19-8

Formula: C₉CH₁₅N₃N₂O₁₀P₂S

Color and Shape: Neat

Molecular weight: 462.25

Ref: TR-T350777

6-Thioguanosine-5'-O-diphosphate sodium salt - 10mM aqueous solution

CAS: 16541-19-8

6-Thioguanosine-5'-O-diphosphate sodium salt is a nucleotide derivative of guanosine that binds to the regulatory site of ATP synthase in the chloroplast. It is an allosteric inhibitor that has been shown to inhibit the synthesis of proteins and chlorophyll, as well as ATP synthesis in plastids of plants. 6-Thioguanosine-5'-O-diphosphate sodium salt has been shown to be effective at inhibiting protein synthesis in mammalian cells, which may be due to its ability to bind to the metabotropic glutamate receptor. The molecule was also found to bind with high affinity to a ternary complex that includes glutamine, glutamate, and ammonia.

Formula: C₁₀H₁₅N₅O₁₀P₂SxNa

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 459.27 g/mol

Ref: 3D-NT36522

6-T-GDP

CAS: 16541-19-8

6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of thiopurine. It inhibits the activity of Rac1, thereby reducing the transcription of inflammatory factors and the expression of cell adhesion molecules, which ultimately suppresses leukocyte migration and the occurrence of tissue inflammation.

Formula: C₁₀H₁₅N₅O₁₀P₂S

Color and Shape: Solid

Molecular weight: 459.27

Ref: TM-T88704