CAS 165668-41-7

Indisulam

Description:

Indisulam, with the CAS number 165668-41-7, is a small molecule that has garnered attention in the field of cancer research. It is classified as a sulfonamide compound and functions primarily as an antitumor agent. Indisulam exhibits its pharmacological effects by inhibiting the enzyme carbonic anhydrase, which plays a crucial role in various physiological processes, including pH regulation and ion transport. This inhibition can lead to altered cellular metabolism and growth inhibition in cancer cells. The compound has shown promise in preclinical studies and early-phase clinical trials, particularly in the treatment of solid tumors. Indisulam is typically administered intravenously and has a relatively short half-life, necessitating careful consideration of dosing regimens. Its safety profile and potential side effects are still under investigation, but like many chemotherapeutic agents, it may be associated with myelosuppression and gastrointestinal disturbances. Overall, Indisulam represents a novel approach in targeted cancer therapy, highlighting the ongoing efforts to develop effective treatments for malignancies.

Formula: C₁₄H₁₂ClN₃O₄S₂

InChI: InChI=1S/C14H12ClN3O4S2/c15-12-8-17-14-11(12)2-1-3-13(14)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20)

InChI key: InChIKey=SETFNECMODOHTO-UHFFFAOYSA-N

SMILES: N(S(=O)(=O)C1=CC=C(S(N)(=O)=O)C=C1)C2=C3C(C(Cl)=CN3)=CC=C2

Synonyms:

• 1,4-Benzenedisulfonamide, N-(3-chloro-1H-indol-7-yl)-
• 1,4-Benzenedisulfonamide, N¹-(3-chloro-1H-indol-7-yl)-
• E 7070
• N-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide
• N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
• N¹-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide
• 1,4-Benzenedisulfonamide, N1-(3-chloro-1H-indol-7-yl)-
• N1-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide
• Indisulam

1,4-Benzenedisulfonamide, N1-(3-chloro-1H-indol-7-yl)-

CAS: 165668-41-7

Formula: C₁₄H₁₂ClN₃O₄S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 385.8458

Ref: IN-DA001W9L

N-(3-Chloro-1H-Indol-7-Yl)Benzene-1,4-Disulfonamide

CAS: 165668-41-7

N-(3-Chloro-1H-Indol-7-Yl)Benzene-1,4-Disulfonamide

Purity: 99%

Molecular weight: 385.85g/mol

Ref: 54-OR1023865

Indisulam

CAS: 165668-41-7

Indisulam

Purity: ≥98%

Molecular weight: 385.85g/mol

Ref: 54-BUP14327

Indisulam

CAS: 165668-41-7

Indisulam (E 7070) is a dual-action anticancer drug, blocking G1/S cell cycle transition by degrading cyclin E and activating p53/p21.

Formula: C₁₄H₁₂ClN₃O₄S₂

Purity: 98.68% - 99.77%

Color and Shape: Solid

Molecular weight: 385.85

Ref: TM-T4321

Indisulam

CAS: 165668-41-7

Formula: C₁₄H₁₂ClN₃O₄S₂

Purity: 98%

Molecular weight: 385.84

Ref: 10-F436978