CAS 165739-64-0

Loratadine 2-Chloro IMpurity

Description:

Loratadine 2-Chloro Impurity, identified by the CAS number 165739-64-0, is a chemical compound associated with the antihistamine drug loratadine, which is commonly used to alleviate allergy symptoms. This impurity is characterized by the presence of a chlorine atom, which can influence its chemical behavior and stability. Typically, impurities like this can arise during the synthesis of pharmaceuticals and may affect the purity and efficacy of the final product. The presence of chlorinated compounds can also impact the compound's solubility, reactivity, and potential toxicity. In pharmaceutical contexts, the identification and quantification of such impurities are crucial for ensuring compliance with regulatory standards and maintaining drug safety. Analytical techniques such as chromatography and mass spectrometry are often employed to detect and analyze impurities like Loratadine 2-Chloro Impurity. Understanding the characteristics of this impurity is essential for pharmaceutical development and quality control processes.

Formula: C₂₂H₂₂Cl₂N₂O₂

Synonyms:

• 1-Piperidinecarboxylic acid, 4-(2,8-dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester
• ethyl 4-(2,8-dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate
• Loratadine Impurity 26
• Ethyl 4-(2,8-Dichloro-5,6-dihydro-1
• Loratadine 2-Chloro IMpurity

Ethyl 4-(2,8-Dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate

CAS: 165739-64-0

Color and Shape: Neat

Ref: 86-MM0257.20

2-Chloro Loratadine

Controlled Product

CAS: 165739-64-0

Applications 2-Chloro Loratadine is an impurity of Loratadine (L469575), a nonsedating-type histamine H1-Receptor blocker.
References U.S. (1998), US 5719148 A 19980217. PCT Int. Appl. (1995), WO 9510515 A1 19950420.

Formula: C₂₂H₂₂Cl₂N₂O₂

Color and Shape: Neat

Molecular weight: 417.33

Ref: TR-C375470